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5ica

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==Structure of the CTD complex of UTP12, Utp13, Utp1 and Utp21==
==Structure of the CTD complex of UTP12, Utp13, Utp1 and Utp21==
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<StructureSection load='5ica' size='340' side='right' caption='[[5ica]], [[Resolution|resolution]] 3.51&Aring;' scene=''>
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<StructureSection load='5ica' size='340' side='right'caption='[[5ica]], [[Resolution|resolution]] 3.51&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5ica]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ICA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ICA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5ica]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Chaetomium_thermophilum_var._thermophilum_DSM_1495 Chaetomium thermophilum var. thermophilum DSM 1495]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ICA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ICA FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ic7|5ic7]], [[5ic8|5ic8]], [[5ic9|5ic9]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.507&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ica FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ica OCA], [http://pdbe.org/5ica PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ica RCSB], [http://www.ebi.ac.uk/pdbsum/5ica PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ica ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ica FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ica OCA], [https://pdbe.org/5ica PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ica RCSB], [https://www.ebi.ac.uk/pdbsum/5ica PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ica ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/G0RZL9_CHATD G0RZL9_CHATD]
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Ribosome assembly is an essential and conserved cellular process in eukaryotes that requires numerous assembly factors. The six-subunit UTPB complex is an essential component of the 90S precursor of the small ribosomal subunit. Here, we analyzed the molecular architecture of UTPB using an integrative structural biology approach. We mapped the major interactions that associate each of six UTPB proteins. Crystallographic studies showed that Utp1, Utp21, Utp12 and Utp13 are evolutionarily related and form a dimer of dimers (Utp1-Utp21, Utp12-Utp13) through their homologous helical C-terminal domains. Molecular docking with crosslinking restraints showed that the WD domains of Utp12 and Utp13 are associated, as are the WD domains of Utp1, Utp21 and Utp18. Electron microscopy images of the entire UTPB complex revealed that it predominantly adopts elongated conformations and possesses internal flexibility. We also determined crystal structures of the WD domain of Utp18 and the HAT and deviant HAT domains of Utp6. A structural model of UTPB was derived based on these data.
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Integrative structural analysis of the UTPB complex, an early assembly factor for eukaryotic small ribosomal subunits.,Zhang C, Sun Q, Chen R, Chen X, Lin J, Ye K Nucleic Acids Res. 2016 Jun 21. pii: gkw562. PMID:27330138<ref>PMID:27330138</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 5ica" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Ye, K]]
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[[Category: Chaetomium thermophilum var. thermophilum DSM 1495]]
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[[Category: Zhang, C]]
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[[Category: Large Structures]]
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[[Category: 90s preribosome]]
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[[Category: Ye K]]
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[[Category: Protein binding]]
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[[Category: Zhang C]]
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[[Category: Rrna processing]]
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[[Category: Structural protein]]
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Current revision

Structure of the CTD complex of UTP12, Utp13, Utp1 and Utp21

PDB ID 5ica

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