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6pcv
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 6pcv is ON HOLD Authors: Description: Category: Unreleased Structures) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Single Particle Reconstruction of Phosphatidylinositol (3,4,5) trisphosphate-dependent Rac exchanger 1 bound to G protein beta gamma subunits== | |
| + | <SX load='6pcv' size='340' side='right' viewer='molstar' caption='[[6pcv]], [[Resolution|resolution]] 3.20Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6pcv]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PCV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PCV FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.2Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6pcv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pcv OCA], [https://pdbe.org/6pcv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6pcv RCSB], [https://www.ebi.ac.uk/pdbsum/6pcv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6pcv ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PREX1_HUMAN PREX1_HUMAN] Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils. | ||
| - | + | ==See Also== | |
| - | + | *[[Transducin 3D structures|Transducin 3D structures]] | |
| - | + | __TOC__ | |
| - | [[Category: | + | </SX> |
| + | [[Category: Bos taurus]] | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Cash JN]] | ||
| + | [[Category: Cianfrocco MA]] | ||
| + | [[Category: Tesmer JJG]] | ||
Current revision
Single Particle Reconstruction of Phosphatidylinositol (3,4,5) trisphosphate-dependent Rac exchanger 1 bound to G protein beta gamma subunits
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