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6pwe

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==Cryo-EM structure of nucleosome core particle==
==Cryo-EM structure of nucleosome core particle==
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<StructureSection load='6pwe' size='340' side='right'caption='[[6pwe]], [[Resolution|resolution]] 3.95&Aring;' scene=''>
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<SX load='6pwe' size='340' side='right' viewer='molstar' caption='[[6pwe]], [[Resolution|resolution]] 3.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6pwe]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PWE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PWE FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6pwe]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PWE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PWE FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6pwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pwe OCA], [http://pdbe.org/6pwe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pwe RCSB], [http://www.ebi.ac.uk/pdbsum/6pwe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pwe ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.95&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6pwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pwe OCA], [https://pdbe.org/6pwe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6pwe RCSB], [https://www.ebi.ac.uk/pdbsum/6pwe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6pwe ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/A0A0B4KFZ9_DROME A0A0B4KFZ9_DROME]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.[RuleBase:RU000528][SAAS:SAAS00581158]
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[https://www.uniprot.org/uniprot/H3_DROME H3_DROME]
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==See Also==
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*[[Histone 3D structures|Histone 3D structures]]
__TOC__
__TOC__
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</StructureSection>
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</SX>
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[[Category: Drosophila melanogaster]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Chittori, S]]
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[[Category: Synthetic construct]]
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[[Category: Subramaniam, S]]
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[[Category: Chittori S]]
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[[Category: Dna]]
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[[Category: Subramaniam S]]
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[[Category: Dna-binding protein]]
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[[Category: Histone]]
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[[Category: Nucleosome]]
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[[Category: Structural protein-dna complex]]
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Current revision

Cryo-EM structure of nucleosome core particle

6pwe, resolution 3.95Å

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