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6ugm

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==Structural basis of COMPASS eCM recognition of an unmodified nucleosome==
==Structural basis of COMPASS eCM recognition of an unmodified nucleosome==
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<StructureSection load='6ugm' size='340' side='right'caption='[[6ugm]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
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<SX load='6ugm' size='340' side='right' viewer='molstar' caption='[[6ugm]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6ugm]] is a 18 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UGM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6UGM FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6ugm]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Kluyveromyces_lactis_NRRL_Y-1140 Kluyveromyces lactis NRRL Y-1140], [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UGM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6UGM FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.7&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ugm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ugm OCA], [http://pdbe.org/6ugm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ugm RCSB], [http://www.ebi.ac.uk/pdbsum/6ugm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ugm ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ugm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ugm OCA], [https://pdbe.org/6ugm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ugm RCSB], [https://www.ebi.ac.uk/pdbsum/6ugm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ugm ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SET1_KLULA SET1_KLULA]] Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation. [[http://www.uniprot.org/uniprot/H4_XENLA H4_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [[http://www.uniprot.org/uniprot/H2B11_XENLA H2B11_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
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[https://www.uniprot.org/uniprot/Q92133_XENLA Q92133_XENLA]
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==See Also==
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*[[Histone 3D structures|Histone 3D structures]]
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*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]]
__TOC__
__TOC__
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</StructureSection>
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</SX>
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[[Category: Histone-lysine N-methyltransferase]]
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[[Category: Kluyveromyces lactis NRRL Y-1140]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Hsu, P L]]
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[[Category: Synthetic construct]]
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[[Category: Shi, H]]
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[[Category: Xenopus laevis]]
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[[Category: Zheng, N]]
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[[Category: Hsu PL]]
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[[Category: Chromatin]]
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[[Category: Shi H]]
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[[Category: Complex]]
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[[Category: Zheng N]]
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[[Category: Epigenetic]]
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[[Category: Methyltransferase]]
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[[Category: Nucleosome]]
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[[Category: Transferase-structural protein-dna complex]]
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Current revision

Structural basis of COMPASS eCM recognition of an unmodified nucleosome

6ugm, resolution 3.70Å

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