This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1dem

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:49, 20 March 2024) (edit) (undo)
 
(16 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1dem.gif|left|200px]]
 
-
{{Structure
+
==PROTEINASE INHIBITOR HOMOLOGUES AS POTASSIUM CHANNEL BLOCKERS==
-
|PDB= 1dem |SIZE=350|CAPTION= <scene name='initialview01'>1dem</scene>
+
<StructureSection load='1dem' size='340' side='right'caption='[[1dem]]' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND=
+
<table><tr><td colspan='2'>[[1dem]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Dendroaspis_polylepis_polylepis Dendroaspis polylepis polylepis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DEM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DEM FirstGlance]. <br>
-
|ACTIVITY=
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
|GENE=
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dem FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dem OCA], [https://pdbe.org/1dem PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dem RCSB], [https://www.ebi.ac.uk/pdbsum/1dem PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dem ProSAT]</span></td></tr>
-
|DOMAIN=
+
</table>
-
|RELATEDENTRY=[[1den|1DEN]]
+
== Function ==
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dem FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dem OCA], [http://www.ebi.ac.uk/pdbsum/1dem PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1dem RCSB]</span>
+
[https://www.uniprot.org/uniprot/VKTH1_DENPO VKTH1_DENPO] Serine protease inhibitor homolog that blocks voltage-gated potassium channels (Kv1.1/KCNA1, Kv1.2/KCNA2, and Kv1.6/KCNA6) (IC(50)=0.13-50 nM).<ref>PMID:8612784</ref>
-
}}
+
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/de/1dem_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dem ConSurf].
 +
<div style="clear:both"></div>
-
'''PROTEINASE INHIBITOR HOMOLOGUES AS POTASSIUM CHANNEL BLOCKERS'''
+
==See Also==
-
 
+
*[[Dendrotoxin|Dendrotoxin]]
-
 
+
== References ==
-
==Overview==
+
<references/>
-
We report here the NMR structure of dendrotoxin I, a powerful potassium channel blocker from the venom of the African Elapidae snake Dendroaspis polylepis polylepis (black mamba), calculated from an experimentally-derived set of 719 geometric restraints. The backbone of the toxin superimposes on bovine pancreatic trypsin inhibitor (BPTI) with a root-mean-square deviation of &lt; 1.7 A. The surface electrostatic potential calculated for dendrotoxin I and BPTI, reveal an important difference which might account for the differences in function of the two proteins. These proteins may provide examples of adaptation for specific and diverse biological functions while at the same time maintaining the overall three-dimensional structure of a common ancestor.
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
-
1DEM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Dendroaspis_polylepis_polylepis Dendroaspis polylepis polylepis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DEM OCA].
+
-
 
+
-
==Reference==
+
-
Proteinase inhibitor homologues as potassium channel blockers., Lancelin JM, Foray MF, Poncin M, Hollecker M, Marion D, Nat Struct Biol. 1994 Apr;1(4):246-50. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7544683 7544683]
+
[[Category: Dendroaspis polylepis polylepis]]
[[Category: Dendroaspis polylepis polylepis]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Foray, M F.]]
+
[[Category: Foray M-F]]
-
[[Category: Lancelin, J M.]]
+
[[Category: Lancelin J-M]]
-
[[Category: venom(potassium channel inhibitor)]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:40:05 2008''
+

Current revision

PROTEINASE INHIBITOR HOMOLOGUES AS POTASSIUM CHANNEL BLOCKERS

PDB ID 1dem

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1dem"
Personal tools