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1dip

From Proteopedia

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[[Image:1dip.png|left|200px]]
 
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{{STRUCTURE_1dip| PDB=1dip | SCENE= }}
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==THE SOLUTION STRUCTURE OF PORCINE DELTA-SLEEP-INDUCING PEPTIDE IMMUNOREACTIVE PEPTIDE, NMR, 10 STRUCTURES==
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<StructureSection load='1dip' size='340' side='right'caption='[[1dip]]' scene=''>
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===THE SOLUTION STRUCTURE OF PORCINE DELTA-SLEEP-INDUCING PEPTIDE IMMUNOREACTIVE PEPTIDE, NMR, 10 STRUCTURES===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1dip]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DIP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DIP FirstGlance]. <br>
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{{ABSTRACT_PUBMED_9388238}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dip FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dip OCA], [https://pdbe.org/1dip PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dip RCSB], [https://www.ebi.ac.uk/pdbsum/1dip PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dip ProSAT]</span></td></tr>
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[[1dip]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DIP OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/T22D3_PIG T22D3_PIG] Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities (By similarity).
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<ref group="xtra">PMID:009388238</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/di/1dip_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dip ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
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[[Category: Adermann, K.]]
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[[Category: Adermann K]]
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[[Category: Ejchart, A.]]
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[[Category: Ejchart A]]
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[[Category: Forssmann, W G.]]
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[[Category: Forssmann WG]]
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[[Category: Jaenicke, R.]]
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[[Category: Jaenicke R]]
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[[Category: Roesch, P.]]
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[[Category: Roesch P]]
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[[Category: Schindler, T.]]
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[[Category: Schindler T]]
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[[Category: Seidel, G.]]
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[[Category: Seidel G]]
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[[Category: Delta-sleep-inducing peptide immunoreactive peptide]]
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[[Category: Leucine zipper]]
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[[Category: Pig]]
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Current revision

THE SOLUTION STRUCTURE OF PORCINE DELTA-SLEEP-INDUCING PEPTIDE IMMUNOREACTIVE PEPTIDE, NMR, 10 STRUCTURES

PDB ID 1dip

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