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1dlp

From Proteopedia

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[[Image:1dlp.gif|left|200px]]
 
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==STRUCTURAL CHARACTERIZATION OF THE NATIVE FETUIN-BINDING PROTEIN SCILLA CAMPANULATA AGGLUTININ (SCAFET): A NOVEL TWO-DOMAIN LECTIN==
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The line below this paragraph, containing "STRUCTURE_1dlp", creates the "Structure Box" on the page.
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<StructureSection load='1dlp' size='340' side='right'caption='[[1dlp]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1dlp]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Hyacinthoides_hispanica Hyacinthoides hispanica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DLP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DLP FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dlp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dlp OCA], [https://pdbe.org/1dlp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dlp RCSB], [https://www.ebi.ac.uk/pdbsum/1dlp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dlp ProSAT]</span></td></tr>
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{{STRUCTURE_1dlp| PDB=1dlp | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9ZP48_HYAHI Q9ZP48_HYAHI]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dl/1dlp_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dlp ConSurf].
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<div style="clear:both"></div>
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'''STRUCTURAL CHARACTERIZATION OF THE NATIVE FETUIN-BINDING PROTEIN SCILLA CAMPANULATA AGGLUTININ (SCAFET): A NOVEL TWO-DOMAIN LECTIN'''
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==See Also==
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*[[Agglutinin 3D structures|Agglutinin 3D structures]]
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__TOC__
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==Overview==
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</StructureSection>
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The three-dimensional structure of a 244-residue, multivalent, fetuin-binding lectin, SCAfet, isolated from bluebell (Scilla campanulata) bulbs, has been solved at 3.3 A resolution by molecular replacement using the coordinates of the 119-residue, mannose-binding lectin, SCAman, also from bluebell bulbs. Unlike most monocot mannose-binding lectins, such as Galanthus nivalis agglutinin from snowdrop bulbs, which fold into a single domain, SCAfet contains two domains with approximately 55% sequence identity, joined by a linker peptide. Both domains are made up of a 12-stranded beta-prism II fold, with three putative carbohydrate-binding sites, one on each subdomain. SCAfet binds to the complex saccharides of various animal glycoproteins but not to simple sugars.
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==About this Structure==
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1DLP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Hyacinthoides_hispanica Hyacinthoides hispanica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DLP OCA].
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==Reference==
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Structural characterisation of the native fetuin-binding protein Scilla campanulata agglutinin: a novel two-domain lectin., Wright LM, Reynolds CD, Rizkallah PJ, Allen AK, Van Damme EJ, Donovan MJ, Peumans WJ, FEBS Lett. 2000 Feb 18;468(1):19-22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10683433 10683433]
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[[Category: Hyacinthoides hispanica]]
[[Category: Hyacinthoides hispanica]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Allen, A K.]]
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[[Category: Allen AK]]
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[[Category: Donovan, M J.]]
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[[Category: Donovan MJ]]
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[[Category: Peumans, W J.]]
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[[Category: Peumans WJ]]
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[[Category: Reynolds, C D.]]
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[[Category: Reynolds CD]]
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[[Category: Rizkallah, P J.]]
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[[Category: Rizkallah PJ]]
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[[Category: VanDamme, E J.M.]]
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[[Category: VanDamme EJM]]
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[[Category: Wright, L M.]]
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[[Category: Wright LM]]
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[[Category: Beta prism ii fold]]
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[[Category: Native]]
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[[Category: Two-domain lectin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:59:36 2008''
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Current revision

STRUCTURAL CHARACTERIZATION OF THE NATIVE FETUIN-BINDING PROTEIN SCILLA CAMPANULATA AGGLUTININ (SCAFET): A NOVEL TWO-DOMAIN LECTIN

PDB ID 1dlp

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