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1dqc

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(New page: 200px<br /><applet load="1dqc" size="450" color="white" frame="true" align="right" spinBox="true" caption="1dqc" /> '''SOLUTION STRUCTURE OF TACHYCITIN, AN ANTIMIC...)
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[[Image:1dqc.gif|left|200px]]<br /><applet load="1dqc" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1dqc" />
 
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'''SOLUTION STRUCTURE OF TACHYCITIN, AN ANTIMICROBIAL PROTEIN WITH CHITIN-BINDING FUNCTION'''<br />
 
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==Overview==
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==SOLUTION STRUCTURE OF TACHYCITIN, AN ANTIMICROBIAL PROTEIN WITH CHITIN-BINDING FUNCTION==
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Tachycitin, a 73-residue polypeptide having antimicrobial activity is, present in the hemocyte of horseshoe crab (Tachypleus tridentatus). The, first three-dimensional structure of invertebrate chitin-binding protein, was determined for tachycitin using two-dimensional nuclear magnetic, resonance spectroscopy. The measurements indicate that the structure of, tachycitin is largely divided into N- and C-terminal domains; the former, comprises a three-stranded beta-sheet and the latter a two-stranded, beta-sheet following a short helical turn. The latter structural motif, shares a significant tertiary structural similarity with the, chitin-binding domain of plant chitin-binding protein. This result is, thought to provide faithful experimental evidence to the recent hypothesis, that chitin-binding proteins of invertebrates and plants are correlated by, a convergent evolution process.
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<StructureSection load='1dqc' size='340' side='right'caption='[[1dqc]]' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1dqc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Tachypleus_tridentatus Tachypleus tridentatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DQC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DQC FirstGlance]. <br>
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1DQC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Tachypleus_tridentatus Tachypleus tridentatus] with NH2 as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1DQC OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dqc OCA], [https://pdbe.org/1dqc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dqc RCSB], [https://www.ebi.ac.uk/pdbsum/1dqc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dqc ProSAT]</span></td></tr>
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Chitin-binding proteins in invertebrates and plants comprise a common chitin-binding structural motif., Suetake T, Tsuda S, Kawabata S, Miura K, Iwanaga S, Hikichi K, Nitta K, Kawano K, J Biol Chem. 2000 Jun 16;275(24):17929-32. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10770921 10770921]
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</table>
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[[Category: Single protein]]
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== Function ==
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[https://www.uniprot.org/uniprot/P91818_TACTR P91818_TACTR]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dq/1dqc_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dqc ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Tachypleus tridentatus]]
[[Category: Tachypleus tridentatus]]
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[[Category: Kawabata, S.]]
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[[Category: Kawabata S]]
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[[Category: Kawano, K.]]
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[[Category: Kawano K]]
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[[Category: Miura, K.]]
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[[Category: Miura K]]
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[[Category: Suetake, T.]]
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[[Category: Suetake T]]
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[[Category: Tsuda, S.]]
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[[Category: Tsuda S]]
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[[Category: NH2]]
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[[Category: disulfide-rich]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 03:31:20 2007''
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Current revision

SOLUTION STRUCTURE OF TACHYCITIN, AN ANTIMICROBIAL PROTEIN WITH CHITIN-BINDING FUNCTION

PDB ID 1dqc

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