1dst

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{{Seed}}
 
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[[Image:1dst.png|left|200px]]
 
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==MUTANT OF FACTOR D WITH ENHANCED CATALYTIC ACTIVITY==
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The line below this paragraph, containing "STRUCTURE_1dst", creates the "Structure Box" on the page.
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<StructureSection load='1dst' size='340' side='right'caption='[[1dst]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1dst]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DST OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DST FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dst FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dst OCA], [https://pdbe.org/1dst PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dst RCSB], [https://www.ebi.ac.uk/pdbsum/1dst PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dst ProSAT]</span></td></tr>
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{{STRUCTURE_1dst| PDB=1dst | SCENE= }}
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/CFAD_HUMAN CFAD_HUMAN] Defects in CFD are the cause of complement factor D deficiency (CFDD) [MIM:[https://omim.org/entry/613912 613912]. CFDD is an immunologic disorder characterized by increased susceptibility to bacterial infections, particularly Neisseria infections, due to a defect in the alternative complement pathway.
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== Function ==
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[https://www.uniprot.org/uniprot/CFAD_HUMAN CFAD_HUMAN] Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ds/1dst_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dst ConSurf].
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<div style="clear:both"></div>
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===MUTANT OF FACTOR D WITH ENHANCED CATALYTIC ACTIVITY===
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==See Also==
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*[[Complement factor 3D structures|Complement factor 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_7592653}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 7592653 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7592653}}
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==About this Structure==
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1DST is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DST OCA].
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==Reference==
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<ref group="xtra">PMID:7592653</ref><references group="xtra"/>
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[[Category: Complement factor D]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Narayana, S V.L.]]
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[[Category: Large Structures]]
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[[Category: Volanakis, J E.]]
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[[Category: Narayana SVL]]
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[[Category: Complement activating enzyme]]
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[[Category: Volanakis JE]]
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[[Category: Factor d]]
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[[Category: Hydrolase]]
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[[Category: Serine protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 12:27:38 2009''
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Current revision

MUTANT OF FACTOR D WITH ENHANCED CATALYTIC ACTIVITY

PDB ID 1dst

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