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1dt6

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[[Image:1dt6.jpg|left|200px]]
 
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{{Structure
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==STRUCTURE OF MAMMALIAN CYTOCHROME P450 2C5==
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|PDB= 1dt6 |SIZE=350|CAPTION= <scene name='initialview01'>1dt6</scene>, resolution 3.0&Aring;
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<StructureSection load='1dt6' size='340' side='right'caption='[[1dt6]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SM:SAMARIUM+(III)+ION'>SM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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<table><tr><td colspan='2'>[[1dt6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DT6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DT6 FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Unspecific_monooxygenase Unspecific monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.14.1 1.14.14.1] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SM:SAMARIUM+(III)+ION'>SM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dt6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dt6 OCA], [https://pdbe.org/1dt6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dt6 RCSB], [https://www.ebi.ac.uk/pdbsum/1dt6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dt6 ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dt6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dt6 OCA], [http://www.ebi.ac.uk/pdbsum/1dt6 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1dt6 RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/CP2C5_RABIT CP2C5_RABIT] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dt/1dt6_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dt6 ConSurf].
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<div style="clear:both"></div>
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'''STRUCTURE OF MAMMALIAN CYTOCHROME P450 2C5'''
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==See Also==
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*[[Cytochrome P450 3D structures|Cytochrome P450 3D structures]]
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__TOC__
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==Overview==
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</StructureSection>
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Microsomal cytochrome P450s participate in xenobiotic detoxification, procarcinogen activation, and steroid hormone synthesis. The first structure of a mammalian microsomal P450 suggests that the association of P450s with the endoplasmic reticulum involves a hydrophobic surface of the protein formed by noncontiguous portions of the polypeptide chain. This interaction places the entrance of the putative substrate access channel in or near the membrane and orients the face of the protein proximal to the heme cofactor perpendicular to the plane of the membrane for interaction with the P450 reductase. This structure offers a template for modeling other mammalian P450s and should aid drug discovery and the prediction of drug-drug interactions.
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[[Category: Large Structures]]
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==About this Structure==
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1DT6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DT6 OCA].
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==Reference==
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Mammalian microsomal cytochrome P450 monooxygenase: structural adaptations for membrane binding and functional diversity., Williams PA, Cosme J, Sridhar V, Johnson EF, McRee DE, Mol Cell. 2000 Jan;5(1):121-31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10678174 10678174]
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[[Category: Oryctolagus cuniculus]]
[[Category: Oryctolagus cuniculus]]
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[[Category: Single protein]]
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[[Category: Cosme J]]
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[[Category: Unspecific monooxygenase]]
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[[Category: Johnson EF]]
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[[Category: Cosme, J.]]
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[[Category: McRee DE]]
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[[Category: Johnson, E F.]]
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[[Category: Sridhar V]]
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[[Category: McRee, D E.]]
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[[Category: Williams PA]]
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[[Category: Sridhar, V.]]
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[[Category: Williams, P A.]]
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[[Category: benzo(a)pyrene hydroxylase]]
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[[Category: cyp2c5]]
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[[Category: estradiol 2-hydroxylase]]
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[[Category: membrane protein]]
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[[Category: p450]]
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[[Category: progesterone 21-hydroxylase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:48:16 2008''
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Current revision

STRUCTURE OF MAMMALIAN CYTOCHROME P450 2C5

PDB ID 1dt6

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