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1dt6

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{{Seed}}
 
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[[Image:1dt6.png|left|200px]]
 
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==STRUCTURE OF MAMMALIAN CYTOCHROME P450 2C5==
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The line below this paragraph, containing "STRUCTURE_1dt6", creates the "Structure Box" on the page.
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<StructureSection load='1dt6' size='340' side='right'caption='[[1dt6]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1dt6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DT6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DT6 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SM:SAMARIUM+(III)+ION'>SM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_1dt6| PDB=1dt6 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dt6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dt6 OCA], [https://pdbe.org/1dt6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dt6 RCSB], [https://www.ebi.ac.uk/pdbsum/1dt6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dt6 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CP2C5_RABIT CP2C5_RABIT] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dt/1dt6_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dt6 ConSurf].
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<div style="clear:both"></div>
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===STRUCTURE OF MAMMALIAN CYTOCHROME P450 2C5===
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==See Also==
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*[[Cytochrome P450 3D structures|Cytochrome P450 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_10678174}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 10678174 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10678174}}
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==About this Structure==
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1DT6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DT6 OCA].
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==Reference==
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Mammalian microsomal cytochrome P450 monooxygenase: structural adaptations for membrane binding and functional diversity., Williams PA, Cosme J, Sridhar V, Johnson EF, McRee DE, Mol Cell. 2000 Jan;5(1):121-31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10678174 10678174]
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[[Category: Oryctolagus cuniculus]]
[[Category: Oryctolagus cuniculus]]
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[[Category: Single protein]]
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[[Category: Cosme J]]
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[[Category: Unspecific monooxygenase]]
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[[Category: Johnson EF]]
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[[Category: Cosme, J.]]
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[[Category: McRee DE]]
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[[Category: Johnson, E F.]]
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[[Category: Sridhar V]]
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[[Category: McRee, D E.]]
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[[Category: Williams PA]]
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[[Category: Sridhar, V.]]
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[[Category: Williams, P A.]]
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[[Category: Cyp2c5]]
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[[Category: Estradiol 2-hydroxylase]]
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[[Category: Membrane protein]]
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[[Category: P450]]
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[[Category: Progesterone 21-hydroxylase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:34:58 2008''
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Current revision

STRUCTURE OF MAMMALIAN CYTOCHROME P450 2C5

PDB ID 1dt6

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