This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1dtg

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:53, 20 March 2024) (edit) (undo)
 
(12 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1dtg.png|left|200px]]
 
-
<!--
+
==HUMAN TRANSFERRIN N-LOBE MUTANT H249E==
-
The line below this paragraph, containing "STRUCTURE_1dtg", creates the "Structure Box" on the page.
+
<StructureSection load='1dtg' size='340' side='right'caption='[[1dtg]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1dtg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DTG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DTG FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
-
{{STRUCTURE_1dtg| PDB=1dtg | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dtg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dtg OCA], [https://pdbe.org/1dtg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dtg RCSB], [https://www.ebi.ac.uk/pdbsum/1dtg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dtg ProSAT]</span></td></tr>
 +
</table>
 +
== Disease ==
 +
[https://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN] Defects in TF are the cause of atransferrinemia (ATRAF) [MIM:[https://omim.org/entry/209300 209300]. Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia.<ref>PMID:11110675</ref> <ref>PMID:15466165</ref>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dt/1dtg_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dtg ConSurf].
 +
<div style="clear:both"></div>
-
===HUMAN TRANSFERRIN N-LOBE MUTANT H249E===
+
==See Also==
-
 
+
*[[Transferrin 3D structures|Transferrin 3D structures]]
-
 
+
== References ==
-
<!--
+
<references/>
-
The line below this paragraph, {{ABSTRACT_PUBMED_10684598}}, adds the Publication Abstract to the page
+
__TOC__
-
(as it appears on PubMed at http://www.pubmed.gov), where 10684598 is the PubMed ID number.
+
</StructureSection>
-
-->
+
-
{{ABSTRACT_PUBMED_10684598}}
+
-
 
+
-
==About this Structure==
+
-
1DTG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DTG OCA].
+
-
 
+
-
==Reference==
+
-
Mutation of the iron ligand His 249 to Glu in the N-lobe of human transferrin abolishes the dilysine "trigger" but does not significantly affect iron release., MacGillivray RT, Bewley MC, Smith CA, He QY, Mason AB, Woodworth RC, Baker EN, Biochemistry. 2000 Feb 15;39(6):1211-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10684598 10684598]
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Bewley, M C.]]
+
[[Category: Bewley MC]]
-
[[Category: He, Q Y.]]
+
[[Category: He QY]]
-
[[Category: MacGillivray, R T.]]
+
[[Category: MacGillivray RT]]
-
[[Category: Mason, A B.]]
+
[[Category: Mason AB]]
-
[[Category: Smith, C A.]]
+
[[Category: Smith CA]]
-
[[Category: 3d- structure]]
+
-
[[Category: Glycoprotein]]
+
-
[[Category: Iron transport]]
+
-
[[Category: Metal-binding]]
+
-
[[Category: Polymorphism]]
+
-
[[Category: Repeat]]
+
-
[[Category: Signal]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:35:26 2008''
+

Current revision

HUMAN TRANSFERRIN N-LOBE MUTANT H249E

PDB ID 1dtg

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1dtg"
Personal tools