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1dwq
From Proteopedia
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| - | [[Image:1dwq.png|left|200px]] | ||
| - | + | ==Crystal Structure of Hydroxynitrile Lyase from Manihot esculenta in Complex with Substrates Acetone and Chloroacetone:Implications for the Mechanism of Cyanogenesis== | |
| - | + | <StructureSection load='1dwq' size='340' side='right'caption='[[1dwq]], [[Resolution|resolution]] 2.20Å' scene=''> | |
| - | === | + | == Structural highlights == |
| - | + | <table><tr><td colspan='2'>[[1dwq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Manihot_esculenta Manihot esculenta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DWQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DWQ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATO:CHLOROACETONE'>ATO</scene>, <scene name='pdbligand=CSA:S-ACETONYLCYSTEINE'>CSA</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dwq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dwq OCA], [https://pdbe.org/1dwq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dwq RCSB], [https://www.ebi.ac.uk/pdbsum/1dwq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dwq ProSAT]</span></td></tr> |
| - | [[1dwq]] is a 2 chain structure with sequence from [ | + | </table> |
| - | + | == Function == | |
| - | == | + | [https://www.uniprot.org/uniprot/HNL_MANES HNL_MANES] Involved in cyanogenesis, the release of HCN from injured tissues. Decomposes a varieties of (R) or (S) cyanohydrins into HCN and the corresponding aldehydes and ketones. The natural substrate of this enzyme is (S)-acetone cyanohydrin. |
| - | < | + | == Evolutionary Conservation == |
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dw/1dwq_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dwq ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Manihot esculenta]] | [[Category: Manihot esculenta]] | ||
| - | + | [[Category: Effenberger F]] | |
| - | [[Category: Effenberger | + | [[Category: Forster S]] |
| - | [[Category: Forster | + | [[Category: Lauble H]] |
| - | [[Category: Lauble | + | [[Category: Mielich B]] |
| - | [[Category: Mielich | + | [[Category: Wajant H]] |
| - | [[Category: Wajant | + | |
| - | + | ||
| - | + | ||
Current revision
Crystal Structure of Hydroxynitrile Lyase from Manihot esculenta in Complex with Substrates Acetone and Chloroacetone:Implications for the Mechanism of Cyanogenesis
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