This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1dx0

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:55, 20 March 2024) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1dx0.png|left|200px]]
 
-
<!--
+
==BOVINE PRION PROTEIN RESIDUES 23-230==
-
The line below this paragraph, containing "STRUCTURE_1dx0", creates the "Structure Box" on the page.
+
<StructureSection load='1dx0' size='340' side='right'caption='[[1dx0]]' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1dx0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DX0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DX0 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dx0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dx0 OCA], [https://pdbe.org/1dx0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dx0 RCSB], [https://www.ebi.ac.uk/pdbsum/1dx0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dx0 ProSAT]</span></td></tr>
-
{{STRUCTURE_1dx0| PDB=1dx0 | SCENE= }}
+
</table>
 +
== Disease ==
 +
[https://www.uniprot.org/uniprot/PRIO_BOVIN PRIO_BOVIN] Note=Variations in PRNP are responsible of transmissible bovine spongiform encephalopathies (BSE), a class of neurodegenerative diseases that affect various mammals. These diseases are caused by abnormally folded prion proteins. BSE can be subdivided into at least three groups: classical, H-type and L-type, with the latter 2 collectively referred to as atypical BSE. Susceptibility or resistance to a BSE disease can be influenced by at least 3 factors related to the host prion protein: protein expression levels, number of octapeptide repeats, and specific polymorphisms. In cattle, as in humans, BSEs can occur as infectious, spontaneous and genetic diseases.
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/PRIO_BOVIN PRIO_BOVIN] May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dx/1dx0_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dx0 ConSurf].
 +
<div style="clear:both"></div>
-
===BOVINE PRION PROTEIN RESIDUES 23-230===
+
==See Also==
-
 
+
*[[Prion 3D structures|Prion 3D structures]]
-
 
+
__TOC__
-
<!--
+
</StructureSection>
-
The line below this paragraph, {{ABSTRACT_PUBMED_10899999}}, adds the Publication Abstract to the page
+
-
(as it appears on PubMed at http://www.pubmed.gov), where 10899999 is the PubMed ID number.
+
-
-->
+
-
{{ABSTRACT_PUBMED_10899999}}
+
-
 
+
-
==About this Structure==
+
-
1DX0 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DX0 OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:10899999</ref><references group="xtra"/>
+
[[Category: Bos taurus]]
[[Category: Bos taurus]]
-
[[Category: Billeter, M.]]
+
[[Category: Large Structures]]
-
[[Category: Lopez-Garcia, F.]]
+
[[Category: Billeter M]]
-
[[Category: Riek, R.]]
+
[[Category: Lopez-Garcia F]]
-
[[Category: Wuthrich, K.]]
+
[[Category: Riek R]]
-
[[Category: Zahn, R.]]
+
[[Category: Wuthrich K]]
-
[[Category: Brain]]
+
[[Category: Zahn R]]
-
[[Category: Prion]]
+
-
[[Category: Repeat]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 21:58:34 2009''
+

Current revision

BOVINE PRION PROTEIN RESIDUES 23-230

PDB ID 1dx0

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1dx0"
Personal tools