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1e20

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[[Image:1e20.gif|left|200px]]<br />
 
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<applet load="1e20" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1e20, resolution 2.02&Aring;" />
 
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'''THE FMN BINDING PROTEIN ATHAL3'''<br />
 
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==Overview==
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==The FMN binding protein AtHal3==
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BACKGROUND: The Arabidopsis thaliana HAL3 gene product encodes for an, FMN-binding protein (AtHal3) that is related to plant growth and salt and, osmotic tolerance. AtHal3 shows sequence homology to ScHal3, a regulatory, subunit of the Saccharomyces cerevisae serine/threonine phosphatase PPz1., It has been proposed that AtHal3 and ScHal3 have similar roles in cellular, physiology, as Arabidopsis transgenic plants that overexpress AtHal3 and, yeast cells that overexpress ScHal3 display similar phenotypes of improved, salt tolerance. The enzymatic activity of AtHal3 has not been, investigated. However, the AtHal3 sequence is homologous to that of EpiD, a flavoprotein from Staphylococcus epidermidis that recognizes a peptidic, substrate and subsequently catalyzes the alpha, ... [[http://ispc.weizmann.ac.il/pmbin/getpm?10986463 (full description)]]
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<StructureSection load='1e20' size='340' side='right'caption='[[1e20]], [[Resolution|resolution]] 2.02&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1e20]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E20 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1E20 FirstGlance]. <br>
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1E20 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]] with NI, FMN and BME as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1E20 OCA]].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.02&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1e20 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e20 OCA], [https://pdbe.org/1e20 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1e20 RCSB], [https://www.ebi.ac.uk/pdbsum/1e20 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1e20 ProSAT]</span></td></tr>
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The X-ray structure of the FMN-binding protein AtHal3 provides the structural basis for the activity of a regulatory subunit involved in signal transduction., Albert A, Martinez-Ripoll M, Espinosa-Ruiz A, Yenush L, Culianez-Macia FA, Serrano R, Structure. 2000 Sep 15;8(9):961-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10986463 10986463]
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HAL3A_ARATH HAL3A_ARATH] Involved in plant growth and salt and osmotic tolerance. Catalyzes the decarboxylation of 4'-phosphopantothenoylcysteine to 4'-phosphopantetheine, a key step in coenzyme A biosynthesis. The enzyme is also able to decarboxylate pantothenoylcysteine to pantothenoylcysteamine.<ref>PMID:12860978</ref> <ref>PMID:16415216</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e2/1e20_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1e20 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Arabidopsis thaliana]]
[[Category: Arabidopsis thaliana]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Albert, A.]]
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[[Category: Albert A]]
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[[Category: Culianez-Macia, F.A.]]
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[[Category: Culianez-Macia FA]]
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[[Category: Espinosa-Ruiz, A.]]
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[[Category: Espinosa-Ruiz A]]
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[[Category: Martinez-Ripoll, M.]]
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[[Category: Martinez-Ripoll M]]
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[[Category: Serrano, R.]]
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[[Category: Serrano R]]
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[[Category: Yenush, L.]]
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[[Category: Yenush L]]
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[[Category: BME]]
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[[Category: FMN]]
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[[Category: NI]]
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[[Category: flavoprotein]]
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[[Category: regulation]]
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[[Category: signal transduction]]
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[[Category: stress]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 15:04:15 2007''
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Current revision

The FMN binding protein AtHal3

PDB ID 1e20

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