1e6f
From Proteopedia
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| - | [[Image:1e6f.png|left|200px]] | ||
| - | + | ==Human MIR-receptor, repeat 11== | |
| - | + | <StructureSection load='1e6f' size='340' side='right'caption='[[1e6f]], [[Resolution|resolution]] 1.75Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1e6f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E6F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1E6F FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75Å</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1e6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e6f OCA], [https://pdbe.org/1e6f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1e6f RCSB], [https://www.ebi.ac.uk/pdbsum/1e6f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1e6f ProSAT]</span></td></tr> | |
| - | == | + | </table> |
| - | [[1e6f]] is a 2 chain structure with sequence from [ | + | == Function == |
| + | [https://www.uniprot.org/uniprot/MPRI_HUMAN MPRI_HUMAN] Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.<ref>PMID:10900005</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e6/1e6f_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1e6f ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
*[[Insulin-like growth factor receptor|Insulin-like growth factor receptor]] | *[[Insulin-like growth factor receptor|Insulin-like growth factor receptor]] | ||
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Dauter | + | [[Category: Dauter M]] |
| - | [[Category: Dauter | + | [[Category: Dauter Z]] |
| - | + | [[Category: Grimme S]] | |
| - | [[Category: Grimme | + | [[Category: Rajashankar KR]] |
| - | [[Category: Rajashankar | + | [[Category: Schmidt B]] |
| - | [[Category: Schmidt | + | [[Category: Uson I]] |
| - | [[Category: Uson | + | [[Category: Von Buelow R]] |
| - | [[Category: | + | [[Category: Von Figura K]] |
| - | [[Category: | + | |
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Current revision
Human MIR-receptor, repeat 11
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Categories: Homo sapiens | Large Structures | Dauter M | Dauter Z | Grimme S | Rajashankar KR | Schmidt B | Uson I | Von Buelow R | Von Figura K
