1e6f

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[[Image:1e6f.png|left|200px]]
 
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{{STRUCTURE_1e6f| PDB=1e6f | SCENE= }}
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==Human MIR-receptor, repeat 11==
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<StructureSection load='1e6f' size='340' side='right'caption='[[1e6f]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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===HUMAN MIR-RECEPTOR, REPEAT 11===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1e6f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E6F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1E6F FirstGlance]. <br>
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{{ABSTRACT_PUBMED_12499540}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1e6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e6f OCA], [https://pdbe.org/1e6f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1e6f RCSB], [https://www.ebi.ac.uk/pdbsum/1e6f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1e6f ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[1e6f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E6F OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/MPRI_HUMAN MPRI_HUMAN] Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.<ref>PMID:10900005</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e6/1e6f_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1e6f ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
*[[Insulin-like growth factor receptor|Insulin-like growth factor receptor]]
*[[Insulin-like growth factor receptor|Insulin-like growth factor receptor]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:012499540</ref><ref group="xtra">PMID:011867533</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Buelow, R Von.]]
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[[Category: Large Structures]]
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[[Category: Dauter, M.]]
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[[Category: Dauter M]]
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[[Category: Dauter, Z.]]
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[[Category: Dauter Z]]
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[[Category: Figura, K Von.]]
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[[Category: Grimme S]]
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[[Category: Grimme, S.]]
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[[Category: Rajashankar KR]]
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[[Category: Rajashankar, K R.]]
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[[Category: Schmidt B]]
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[[Category: Schmidt, B.]]
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[[Category: Uson I]]
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[[Category: Uson, I.]]
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[[Category: Von Buelow R]]
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[[Category: Glycoprotein]]
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[[Category: Von Figura K]]
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[[Category: Igf-ii receptor]]
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[[Category: Mir-receptor]]
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[[Category: Receptor]]
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[[Category: Transport]]
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Current revision

Human MIR-receptor, repeat 11

PDB ID 1e6f

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