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1e8u

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[[Image:1e8u.png|left|200px]]
 
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{{STRUCTURE_1e8u| PDB=1e8u | SCENE= }}
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==Structure of the multifunctional paramyxovirus hemagglutinin-neuraminidase==
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<StructureSection load='1e8u' size='340' side='right'caption='[[1e8u]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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===STRUCTURE OF THE MULTIFUNCTIONAL PARAMYXOVIRUS HEMAGGLUTININ-NEURAMINIDASE===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1e8u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Avian_orthoavulavirus_1 Avian orthoavulavirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E8U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1E8U FirstGlance]. <br>
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{{ABSTRACT_PUBMED_11062565}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SLB:5-N-ACETYL-BETA-D-NEURAMINIC+ACID'>SLB</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1e8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e8u OCA], [https://pdbe.org/1e8u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1e8u RCSB], [https://www.ebi.ac.uk/pdbsum/1e8u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1e8u ProSAT]</span></td></tr>
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[[1e8u]] is a 2 chain structure of [[Hemagglutinin]] with sequence from [http://en.wikipedia.org/wiki/Newcastle_disease_virus Newcastle disease virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E8U OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HN_NDVK HN_NDVK] Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion (By similarity). Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e8/1e8u_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1e8u ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Hemagglutinin|Hemagglutinin]]
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*[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:011062565</ref><ref group="xtra">PMID:010772993</ref><references group="xtra"/>
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[[Category: Avian orthoavulavirus 1]]
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[[Category: Exo-alpha-sialidase]]
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[[Category: Large Structures]]
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[[Category: Newcastle disease virus]]
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[[Category: Crennell S]]
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[[Category: Crennell, S.]]
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[[Category: Portner A]]
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[[Category: Portner, A.]]
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[[Category: Takimoto T]]
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[[Category: Takimoto, T.]]
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[[Category: Taylor G]]
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[[Category: Taylor, G.]]
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[[Category: Hemagglutinin]]
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[[Category: Hydrolase]]
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[[Category: Neuraminidase]]
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[[Category: Sialidase]]
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Current revision

Structure of the multifunctional paramyxovirus hemagglutinin-neuraminidase

PDB ID 1e8u

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