This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1ejn

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "1ejn" [edit=sysop:move=sysop])
Current revision (10:03, 20 March 2024) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1ejn.png|left|200px]]
 
-
{{STRUCTURE_1ejn| PDB=1ejn | SCENE= }}
+
==UROKINASE PLASMINOGEN ACTIVATOR B-CHAIN INHIBITOR COMPLEX==
-
 
+
<StructureSection load='1ejn' size='340' side='right'caption='[[1ejn]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
-
===UROKINASE PLASMINOGEN ACTIVATOR B-CHAIN INHIBITOR COMPLEX===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[1ejn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EJN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EJN FirstGlance]. <br>
-
{{ABSTRACT_PUBMED_10805774}}
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AGB:N-(1-ADAMANTYL)-N-(4-GUANIDINOBENZYL)UREA'>AGB</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
==About this Structure==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ejn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ejn OCA], [https://pdbe.org/1ejn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ejn RCSB], [https://www.ebi.ac.uk/pdbsum/1ejn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ejn ProSAT]</span></td></tr>
-
[[1ejn]] is a 1 chain structure of [[Urokinase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EJN OCA].
+
</table>
 +
== Disease ==
 +
[https://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN] Defects in PLAU are the cause of Quebec platelet disorder (QPD) [MIM:[https://omim.org/entry/601709 601709]. QPD is an autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins.<ref>PMID:20007542</ref>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN] Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ej/1ejn_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ejn ConSurf].
 +
<div style="clear:both"></div>
==See Also==
==See Also==
-
*[[Urokinase|Urokinase]]
+
*[[Urokinase 3D Structures|Urokinase 3D Structures]]
-
 
+
== References ==
-
==Reference==
+
<references/>
-
<ref group="xtra">PMID:010805774</ref><references group="xtra"/>
+
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: U-plasminogen activator]]
+
[[Category: Large Structures]]
-
[[Category: Bode, W.]]
+
[[Category: Arroyo de Prada N]]
-
[[Category: Huber, R.]]
+
[[Category: Bode W]]
-
[[Category: Jacob, U.]]
+
[[Category: Huber R]]
-
[[Category: Magdolen, V.]]
+
[[Category: Jacob U]]
-
[[Category: Moroder, L.]]
+
[[Category: Magdolen V]]
-
[[Category: Prada, N Arroyo de.]]
+
[[Category: Moroder L]]
-
[[Category: Sperl, S.]]
+
[[Category: Sperl S]]
-
[[Category: Stuerzebecher, J.]]
+
[[Category: Stuerzebecher J]]
-
[[Category: Wilhelm, O G.]]
+
[[Category: Wilhelm OG]]
-
[[Category: Human]]
+
-
[[Category: Hydrolase]]
+
-
[[Category: Inhibitor complex]]
+
-
[[Category: Plasminogen activator]]
+
-
[[Category: Upa]]
+
-
[[Category: Urokinase]]
+

Current revision

UROKINASE PLASMINOGEN ACTIVATOR B-CHAIN INHIBITOR COMPLEX

PDB ID 1ejn

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ejn"
Personal tools