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1ejn

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{{Seed}}
 
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[[Image:1ejn.png|left|200px]]
 
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<!--
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==UROKINASE PLASMINOGEN ACTIVATOR B-CHAIN INHIBITOR COMPLEX==
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The line below this paragraph, containing "STRUCTURE_1ejn", creates the "Structure Box" on the page.
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<StructureSection load='1ejn' size='340' side='right'caption='[[1ejn]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ejn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EJN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EJN FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AGB:N-(1-ADAMANTYL)-N-(4-GUANIDINOBENZYL)UREA'>AGB</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_1ejn| PDB=1ejn | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ejn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ejn OCA], [https://pdbe.org/1ejn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ejn RCSB], [https://www.ebi.ac.uk/pdbsum/1ejn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ejn ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN] Defects in PLAU are the cause of Quebec platelet disorder (QPD) [MIM:[https://omim.org/entry/601709 601709]. QPD is an autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins.<ref>PMID:20007542</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN] Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ej/1ejn_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ejn ConSurf].
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<div style="clear:both"></div>
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===UROKINASE PLASMINOGEN ACTIVATOR B-CHAIN INHIBITOR COMPLEX===
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==See Also==
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*[[Urokinase 3D Structures|Urokinase 3D Structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_10805774}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 10805774 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_10805774}}
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==About this Structure==
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1EJN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EJN OCA].
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==Reference==
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(4-aminomethyl)phenylguanidine derivatives as nonpeptidic highly selective inhibitors of human urokinase., Sperl S, Jacob U, Arroyo de Prada N, Sturzebecher J, Wilhelm OG, Bode W, Magdolen V, Huber R, Moroder L, Proc Natl Acad Sci U S A. 2000 May 9;97(10):5113-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10805774 10805774]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: U-plasminogen activator]]
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[[Category: Arroyo de Prada N]]
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[[Category: Bode, W.]]
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[[Category: Bode W]]
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[[Category: Huber, R.]]
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[[Category: Huber R]]
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[[Category: Jacob, U.]]
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[[Category: Jacob U]]
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[[Category: Magdolen, V.]]
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[[Category: Magdolen V]]
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[[Category: Moroder, L.]]
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[[Category: Moroder L]]
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[[Category: Prada, N Arroyo de.]]
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[[Category: Sperl S]]
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[[Category: Sperl, S.]]
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[[Category: Stuerzebecher J]]
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[[Category: Stuerzebecher, J.]]
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[[Category: Wilhelm OG]]
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[[Category: Wilhelm, O G.]]
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[[Category: Human]]
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[[Category: Inhibitor complex]]
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[[Category: Plasminogen activator]]
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[[Category: Upa]]
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[[Category: Urokinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 00:51:21 2008''
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Current revision

UROKINASE PLASMINOGEN ACTIVATOR B-CHAIN INHIBITOR COMPLEX

PDB ID 1ejn

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