1el0

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(New page: 200px<br /> <applet load="1el0" size="450" color="white" frame="true" align="right" spinBox="true" caption="1el0" /> '''SOLUTION STRUCTURE OF THE HUMAN CC CHEMOKIN...)
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[[Image:1el0.gif|left|200px]]<br />
 
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<applet load="1el0" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1el0" />
 
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'''SOLUTION STRUCTURE OF THE HUMAN CC CHEMOKINE, I-309'''<br />
 
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==Overview==
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==SOLUTION STRUCTURE OF THE HUMAN CC CHEMOKINE, I-309==
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I-309 is a member of the CC subclass of chemokines and is one of only, three human chemokines known to contain an additional, third disulfide, bond. The three-dimensional solution structure of I-309 was determined by, (1)H nuclear magnetic resonance spectroscopy and dynamic simulated, annealing. The structure of I-309, which remains monomeric at high, concentrations, was determined on the basis of 978 experimental, restraints. The N-terminal region of I-309 was disordered, as has been, previously observed for the CC chemokine eotaxin but not others such as, MCP-1 and RANTES. This was followed in I-309 by a well-ordered region, between residues 13 and 69 that consisted of a 3(10)-helix, a, triple-stranded antiparallel beta-sheet, and finally a C-terminal, alpha-helix. Root-mean-square deviations of 0.61 and 1.16 were observed, for the backbone and heavy atoms, respectively. A comparison of I-309 to, eotaxin and HCC-2 revealed a significant structural change in the, C-terminal region of the protein. The alpha-helix normally present in, chemokines was terminated early and was followed by a short section of, extended strand. These changes were a direct result of the additional, disulfide bond present in this protein. An examination of the I-309, structure will aid in an understanding of the specificity of this protein, with its receptor, CCR8.
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<StructureSection load='1el0' size='340' side='right'caption='[[1el0]]' scene=''>
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== Structural highlights ==
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==Disease==
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<table><tr><td colspan='2'>[[1el0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EL0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EL0 FirstGlance]. <br>
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Known diseases associated with this structure: Asthma, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=601156 601156]], HIV1, resistance to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=601156 601156]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1el0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1el0 OCA], [https://pdbe.org/1el0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1el0 RCSB], [https://www.ebi.ac.uk/pdbsum/1el0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1el0 ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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1EL0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1EL0 OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/CCL1_HUMAN CCL1_HUMAN] Cytokine that is chemotactic for monocytes but not for neutrophils. Binds to CCR8.<ref>PMID:1557400</ref>
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==Reference==
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== Evolutionary Conservation ==
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Human CC chemokine I-309, structural consequences of the additional disulfide bond., Keizer DW, Crump MP, Lee TW, Slupsky CM, Clark-Lewis I, Sykes BD, Biochemistry. 2000 May 23;39(20):6053-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10821677 10821677]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Single protein]]
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Check<jmol>
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[[Category: Clark-Lewis, I.]]
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<jmolCheckbox>
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[[Category: Crump, M.P.]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/el/1el0_consurf.spt"</scriptWhenChecked>
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[[Category: Keizer, D.W.]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: Lee, T.W.]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Slupsky, C.M.]]
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</jmolCheckbox>
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[[Category: Sykes, B.D.]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1el0 ConSurf].
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[[Category: chemokine fold]]
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<div style="clear:both"></div>
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== References ==
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 16:44:30 2007''
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Clark-Lewis I]]
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[[Category: Crump MP]]
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[[Category: Keizer DW]]
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[[Category: Lee TW]]
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[[Category: Slupsky CM]]
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[[Category: Sykes BD]]

Current revision

SOLUTION STRUCTURE OF THE HUMAN CC CHEMOKINE, I-309

PDB ID 1el0

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