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1em2

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(New page: 200px<br /> <applet load="1em2" size="450" color="white" frame="true" align="right" spinBox="true" caption="1em2, resolution 2.2&Aring;" /> '''STAR-RELATED LIPID T...)
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[[Image:1em2.gif|left|200px]]<br />
 
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<applet load="1em2" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1em2, resolution 2.2&Aring;" />
 
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'''STAR-RELATED LIPID TRANSPORT DOMAIN OF MLN64'''<br />
 
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==Overview==
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==Star-related lipid transport domain of MLN64==
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The steroidogenic acute regulatory protein (StAR) regulates acute, steroidogenesis in the adrenal cortex and gonads by promoting the, translocation of cholesterol to the mitochondrial inner membrane where the, first step in steriod biosynthesis is catalyzed. StAR-related lipid, transfer (START) domains occur in proteins involved in lipid transport and, metabolism, signal transduction, and transcriptional regulation. The 2.2 A, resolution crystal structure of the START domain of human MLN64 reported, here reveals an alpha/beta fold built around a U-shaped incomplete, beta-barrel. The interior of the protein encompasses a 26 x 12 x 11 A, hydrophobic tunnel that is large enough to bind a single cholesterol, molecule. The StAR and MLN64 START domains bind 1 mole of 14C cholesterol, per mole of protein in vitro. Based on the START domain structure and, cholesterol binding stoichiometry, it is proposed that StAR acts by, shuttling cholesterol molecules one at a time through the intermembrane, space of the mitochondrion.
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<StructureSection load='1em2' size='340' side='right'caption='[[1em2]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1em2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EM2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EM2 FirstGlance]. <br>
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1EM2 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with TAR as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1EM2 OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=TAR:D(-)-TARTARIC+ACID'>TAR</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1em2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1em2 OCA], [https://pdbe.org/1em2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1em2 RCSB], [https://www.ebi.ac.uk/pdbsum/1em2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1em2 ProSAT]</span></td></tr>
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Structure and lipid transport mechanism of a StAR-related domain., Tsujishita Y, Hurley JH, Nat Struct Biol. 2000 May;7(5):408-14. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10802740 10802740]
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/STAR3_HUMAN STAR3_HUMAN] Binds and transports cholesterol. Promotes steroidogenesis in placenta and brain.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/em/1em2_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1em2 ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Hurley, J.H.]]
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[[Category: Hurley JH]]
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[[Category: Tsujishita, Y.]]
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[[Category: Tsujishita Y]]
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[[Category: TAR]]
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[[Category: beta barrel]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 16:44:49 2007''
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Current revision

Star-related lipid transport domain of MLN64

PDB ID 1em2

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