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1epw

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{{Seed}}
 
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[[Image:1epw.png|left|200px]]
 
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==CRYSTAL STRUCTURE OF CLOSTRIDIUM NEUROTOXIN TYPE B==
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The line below this paragraph, containing "STRUCTURE_1epw", creates the "Structure Box" on the page.
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<StructureSection load='1epw' size='340' side='right'caption='[[1epw]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1epw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EPW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EPW FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_1epw| PDB=1epw | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1epw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1epw OCA], [https://pdbe.org/1epw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1epw RCSB], [https://www.ebi.ac.uk/pdbsum/1epw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1epw ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BXB_CLOBO BXB_CLOBO] Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that cleaves the '76-Gln-|-Phe-77' bond of synaptobrevin-2.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ep/1epw_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1epw ConSurf].
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<div style="clear:both"></div>
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===CRYSTAL STRUCTURE OF CLOSTRIDIUM NEUROTOXIN TYPE B===
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==See Also==
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*[[Botulinum neurotoxin 3D structures|Botulinum neurotoxin 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_10932256}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10932256 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10932256}}
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==About this Structure==
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1EPW is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EPW OCA].
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==Reference==
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<ref group="xtra">PMID:10932256</ref><references group="xtra"/>
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[[Category: Bontoxilysin]]
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[[Category: Clostridium botulinum]]
[[Category: Clostridium botulinum]]
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[[Category: Eswaramoorthy, S.]]
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[[Category: Large Structures]]
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[[Category: Swaminathan, S.]]
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[[Category: Eswaramoorthy S]]
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[[Category: Botulinum]]
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[[Category: Swaminathan S]]
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[[Category: Metalloprotease]]
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[[Category: Neurotoxin]]
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[[Category: Transmembrane]]
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[[Category: Zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 14:53:27 2009''
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Current revision

CRYSTAL STRUCTURE OF CLOSTRIDIUM NEUROTOXIN TYPE B

PDB ID 1epw

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