1esb

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[[Image:1esb.png|left|200px]]
 
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{{STRUCTURE_1esb| PDB=1esb | SCENE= }}
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==DIRECT STRUCTURE OBSERVATION OF AN ACYL-ENZYME INTERMEDIATE IN THE HYDROLYSIS OF AN ESTER SUBSTRATE BY ELASTASE==
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<StructureSection load='1esb' size='340' side='right'caption='[[1esb]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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===DIRECT STRUCTURE OBSERVATION OF AN ACYL-ENZYME INTERMEDIATE IN THE HYDROLYSIS OF AN ESTER SUBSTRATE BY ELASTASE===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1esb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ESB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ESB FirstGlance]. <br>
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{{ABSTRACT_PUBMED_8049229}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BBL:N-[(BENZYLOXY)CARBONYL]-L-ALANINE'>BBL</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1esb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1esb OCA], [https://pdbe.org/1esb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1esb RCSB], [https://www.ebi.ac.uk/pdbsum/1esb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1esb ProSAT]</span></td></tr>
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[[1esb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ESB OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CELA1_PIG CELA1_PIG] Acts upon elastin.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/es/1esb_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1esb ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Elastase|Elastase]]
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*[[Elastase 3D structures|Elastase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:008049229</ref><references group="xtra"/>
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[[Category: Large Structures]]
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[[Category: Pancreatic elastase]]
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[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
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[[Category: Ding, X.]]
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[[Category: Ding X]]
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[[Category: Petsko, G A.]]
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[[Category: Petsko GA]]
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[[Category: Rasmussen, B.]]
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[[Category: Rasmussen B]]
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[[Category: Ringe, D.]]
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[[Category: Ringe D]]
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[[Category: Hydrolase]]
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[[Category: Serine proteinase]]
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Current revision

DIRECT STRUCTURE OBSERVATION OF AN ACYL-ENZYME INTERMEDIATE IN THE HYDROLYSIS OF AN ESTER SUBSTRATE BY ELASTASE

PDB ID 1esb

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