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1esf

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[[Image:1esf.gif|left|200px]]<br />
 
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<applet load="1esf" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1esf, resolution 1.9&Aring;" />
 
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'''STAPHYLOCOCCAL ENTEROTOXIN A'''<br />
 
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==Overview==
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==STAPHYLOCOCCAL ENTEROTOXIN A==
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Staphylococcal enterotoxins are prototype superantigens characterized by, their ability to bind to major histocompatibility complex (MHC) class II, molecules and subsequently activate a large fraction of T-lymphocytes. The, crystal structure of staphylococcal enterotoxin type A (SEA), a 27 kDa, monomeric protein, was determined to 1.9 A resolution with an R-factor of, 19.9% by multiple isomorphous replacement. SEA is a two domain protein, composed of a beta-barrel and a beta-grasp motif demonstrating the same, general structure as staphylococcal enterotoxins SEB and TSST-1. Unique, for SEA, however, is a Zn2+ coordination site involved in MHC class II, binding. Four amino acids including Ser1, His187, His225 and Asp227 were, found to be involved in direct coordination of the metal ion. ... [[http://ispc.weizmann.ac.il/pmbin/getpm?7628431 (full description)]]
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<StructureSection load='1esf' size='340' side='right'caption='[[1esf]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1esf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ESF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ESF FirstGlance]. <br>
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1ESF is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]] with CD as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Sites: CD1 and CD2. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1ESF OCA]].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1esf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1esf OCA], [https://pdbe.org/1esf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1esf RCSB], [https://www.ebi.ac.uk/pdbsum/1esf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1esf ProSAT]</span></td></tr>
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Crystal structure of the superantigen staphylococcal enterotoxin type A., Schad EM, Zaitseva I, Zaitsev VN, Dohlsten M, Kalland T, Schlievert PM, Ohlendorf DH, Svensson LA, EMBO J. 1995 Jul 17;14(14):3292-301. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7628431 7628431]
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</table>
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[[Category: Single protein]]
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== Function ==
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[https://www.uniprot.org/uniprot/ETXA_STAAU ETXA_STAAU] Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness is characterized by high fever, hypotension, diarrhea, shock, and in some cases death.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/es/1esf_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1esf ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Staphylococcus aureus]]
[[Category: Staphylococcus aureus]]
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[[Category: Schad, E.M.]]
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[[Category: Schad EM]]
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[[Category: Svensson, L.A.]]
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[[Category: Svensson LA]]
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[[Category: CD]]
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[[Category: enterotoxin]]
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[[Category: staphylococcal enterotoxin type a]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 15:11:13 2007''
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Current revision

STAPHYLOCOCCAL ENTEROTOXIN A

PDB ID 1esf

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