This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1eso

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:06, 20 March 2024) (edit) (undo)
 
(21 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1eso.gif|left|200px]]<br />
 
-
<applet load="1eso" size="450" color="white" frame="true" align="right" spinBox="true"
 
-
caption="1eso, resolution 2.0&Aring;" />
 
-
'''MONOMERIC CU,ZN SUPEROXIDE DISMUTASE FROM ESCHERICHIA COLI'''<br />
 
-
==Overview==
+
==MONOMERIC CU,ZN SUPEROXIDE DISMUTASE FROM ESCHERICHIA COLI==
-
The first three-dimensional structure of a functional monomeric Cu, Zn, superoxide dismutase (from Escherichia coli, E_SOD) is reported at 2.0 A, resolution (R-factor=16.8%). Compared to the homologous eukaryotic, enzymes, E_SOD displays a perturbed antiparallel beta-barrel structure., The most striking structural features observed include extended amino acid, insertions in the surface 1, 2-loop and S-S subloop, modification of the, disulfide bridge connection, and loss of functional electrostatic, residues, suggesting a modified control of substrate steering toward the, catalytic center. The active site Cu2+ displays a distorted coordination, sphere due to an unusually long bond to the metal-bridging residue His61., Inspection of the crystal packing does not show regions of extended, ... [[http://ispc.weizmann.ac.il/pmbin/getpm?9405149 (full description)]]
+
<StructureSection load='1eso' size='340' side='right'caption='[[1eso]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[1eso]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ESO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ESO FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1eso FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1eso OCA], [https://pdbe.org/1eso PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1eso RCSB], [https://www.ebi.ac.uk/pdbsum/1eso PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1eso ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/SODC_ECOLI SODC_ECOLI] Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/es/1eso_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1eso ConSurf].
 +
<div style="clear:both"></div>
-
==About this Structure==
+
==See Also==
-
1ESO is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]] with ZN and CU as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Superoxide_dismutase Superoxide dismutase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.15.1.1 1.15.1.1]]. Structure known Active Sites: CUL and ZNL. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1ESO OCA]].
+
*[[Superoxide dismutase 3D structures|Superoxide dismutase 3D structures]]
-
 
+
__TOC__
-
==Reference==
+
</StructureSection>
-
Unique structural features of the monomeric Cu,Zn superoxide dismutase from Escherichia coli, revealed by X-ray crystallography., Pesce A, Capasso C, Battistoni A, Folcarelli S, Rotilio G, Desideri A, Bolognesi M, J Mol Biol. 1997 Dec 5;274(3):408-20. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9405149 9405149]
+
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Superoxide dismutase]]
+
[[Category: Battistoni A]]
-
[[Category: Battistoni, A.]]
+
[[Category: Bolognesi M]]
-
[[Category: Bolognesi, M.]]
+
[[Category: Capasso C]]
-
[[Category: Capasso, C.]]
+
[[Category: Desideri A]]
-
[[Category: Desideri, A.]]
+
[[Category: Folcarelli S]]
-
[[Category: Folcarelli, S.]]
+
[[Category: Pesce A]]
-
[[Category: Pesce, A.]]
+
[[Category: Rotilio G]]
-
[[Category: Rotilio, G.]]
+
-
[[Category: CU]]
+
-
[[Category: ZN]]
+
-
[[Category: copper enzymes]]
+
-
[[Category: cu]]
+
-
[[Category: enzyme evolution]]
+
-
[[Category: monomeric superoxide dismutase]]
+
-
[[Category: oxidoreductase]]
+
-
[[Category: x-ray crystal structure]]
+
-
[[Category: zn superoxide dismutase]]
+
-
 
+
-
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 15:11:15 2007''
+

Current revision

MONOMERIC CU,ZN SUPEROXIDE DISMUTASE FROM ESCHERICHIA COLI

PDB ID 1eso

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1eso"
Personal tools