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1ewl

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Current revision (10:07, 20 March 2024) (edit) (undo)
 
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==CRYSTAL STRUCTURE OF CRUZAIN BOUND TO WRR-99==
==CRYSTAL STRUCTURE OF CRUZAIN BOUND TO WRR-99==
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<StructureSection load='1ewl' size='340' side='right' caption='[[1ewl]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='1ewl' size='340' side='right'caption='[[1ewl]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1ewl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trycr Trycr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EWL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1EWL FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1ewl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EWL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EWL FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=R99:N-[3-CARBOXY-2-HYDROXY-PROPIONYL]-D-HOMOPHENYLALANYL-AMINO-2-METHYLBUTANE'>R99</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1aim|1aim]], [[2aim|2aim]], [[1ewm|1ewm]], [[1ewo|1ewo]], [[1ewp|1ewp]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=R99:N-[3-CARBOXY-2-HYDROXY-PROPIONYL]-D-HOMOPHENYLALANYL-AMINO-2-METHYLBUTANE'>R99</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ewl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ewl OCA], [http://pdbe.org/1ewl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ewl RCSB], [http://www.ebi.ac.uk/pdbsum/1ewl PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ewl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ewl OCA], [https://pdbe.org/1ewl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ewl RCSB], [https://www.ebi.ac.uk/pdbsum/1ewl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ewl ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CYSP_TRYCR CYSP_TRYCR]] Hydrolyzes chromogenic peptides at the carboxyl Arg or Lys; requires at least one more amino acid, preferably Arg, Phe, Val or Leu, between the terminal Arg or Lys and the amino-blocking group. The cysteine protease may play an important role in the development and differentiation of the parasites at several stages of their life cycle.
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[https://www.uniprot.org/uniprot/CYSP_TRYCR CYSP_TRYCR] Hydrolyzes chromogenic peptides at the carboxyl Arg or Lys; requires at least one more amino acid, preferably Arg, Phe, Val or Leu, between the terminal Arg or Lys and the amino-blocking group. The cysteine protease may play an important role in the development and differentiation of the parasites at several stages of their life cycle.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ew/1ewl_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ew/1ewl_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Trycr]]
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[[Category: Large Structures]]
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[[Category: Brinen, L S]]
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[[Category: Trypanosoma cruzi]]
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[[Category: Fletterick, R J]]
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[[Category: Brinen LS]]
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[[Category: Gillmor, S A]]
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[[Category: Fletterick RJ]]
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[[Category: Covalent inhibitor]]
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[[Category: Gillmor SA]]
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[[Category: Cruzipain]]
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[[Category: Drug design]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Papain-like cysteine protease]]
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Current revision

CRYSTAL STRUCTURE OF CRUZAIN BOUND TO WRR-99

PDB ID 1ewl

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