This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1ewo

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:07, 20 March 2024) (edit) (undo)
 
(13 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1ewo.jpg|left|200px]]
 
-
<!--
+
==THE CYSTEINE PROTEASE CRUZAIN BOUND TO WRR-204==
-
The line below this paragraph, containing "STRUCTURE_1ewo", creates the "Structure Box" on the page.
+
<StructureSection load='1ewo' size='340' side='right'caption='[[1ewo]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1ewo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EWO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EWO FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=VSC:N-[N-BENZYLOXYCARBONYL-PHENYLALANINYL]-3-AMINO-5-PHENYL-PENTANE-1-SULFONIC+ACID+PHENYL+ESTER'>VSC</scene></td></tr>
-
{{STRUCTURE_1ewo| PDB=1ewo | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ewo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ewo OCA], [https://pdbe.org/1ewo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ewo RCSB], [https://www.ebi.ac.uk/pdbsum/1ewo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ewo ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/CYSP_TRYCR CYSP_TRYCR] Hydrolyzes chromogenic peptides at the carboxyl Arg or Lys; requires at least one more amino acid, preferably Arg, Phe, Val or Leu, between the terminal Arg or Lys and the amino-blocking group. The cysteine protease may play an important role in the development and differentiation of the parasites at several stages of their life cycle.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ew/1ewo_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ewo ConSurf].
 +
<div style="clear:both"></div>
-
'''THE CYSTEINE PROTEASE CRUZAIN BOUND TO WRR-204'''
+
==See Also==
-
 
+
*[[Cruzain|Cruzain]]
-
 
+
__TOC__
-
==About this Structure==
+
</StructureSection>
-
1EWO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EWO OCA].
+
[[Category: Large Structures]]
-
[[Category: Single protein]]
+
[[Category: Trypanosoma cruzi]]
[[Category: Trypanosoma cruzi]]
-
[[Category: Brinen, L S.]]
+
[[Category: Brinen LS]]
-
[[Category: Fletterick, R J.]]
+
[[Category: Fletterick RJ]]
-
[[Category: Gillmor, S A.]]
+
[[Category: Gillmor SA]]
-
[[Category: Covalent inhibitor]]
+
-
[[Category: Cruzipain]]
+
-
[[Category: Cysteine protease]]
+
-
[[Category: Drug design]]
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:36:24 2008''
+

Current revision

THE CYSTEINE PROTEASE CRUZAIN BOUND TO WRR-204

PDB ID 1ewo

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ewo"
Personal tools