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1ey1
From Proteopedia
(Difference between revisions)
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==SOLUTION STRUCTURE OF ESCHERICHIA COLI NUSB== | ==SOLUTION STRUCTURE OF ESCHERICHIA COLI NUSB== | ||
| - | <StructureSection load='1ey1' size='340' side='right'caption='[[1ey1 | + | <StructureSection load='1ey1' size='340' side='right'caption='[[1ey1]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1ey1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EY1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EY1 FirstGlance]. <br> | <table><tr><td colspan='2'>[[1ey1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EY1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EY1 FirstGlance]. <br> | ||
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ey1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ey1 OCA], [https://pdbe.org/1ey1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ey1 RCSB], [https://www.ebi.ac.uk/pdbsum/1ey1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ey1 ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ey1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ey1 OCA], [https://pdbe.org/1ey1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ey1 RCSB], [https://www.ebi.ac.uk/pdbsum/1ey1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ey1 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/NUSB_ECOLI NUSB_ECOLI] One of the proteins essential for the formation of the RNA polymerase antitermination complex in the presence of lambda phage N protein. However, it is involved in the transcription termination process at certain sites during normal bacterial growth. Binds to the BoxA RNA motif. | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ey1 ConSurf]. | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ey1 ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
| - | <div style="background-color:#fffaf0;"> | ||
| - | == Publication Abstract from PubMed == | ||
| - | We have determined the solution structure of NusB, a transcription antitermination protein from Escherichia coli. The structure reveals a novel, all alpha-helical protein fold. NusB mutations that cause a loss of function (NusB5) or alter specificity for RNA targets (NusB101) are localized to surface residues and likely affect RNA-protein or protein-protein interactions. Residues that are highly conserved among homologs stabilize the protein core. The solution structure of E. coli NusB presented here resembles that of Mycobacterium tuberculosis NusB determined by X-ray diffraction, but differs substantially from a solution structure of E. coli NusB reported earlier. | ||
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| - | The structure of the transcriptional antiterminator NusB from Escherichia coli.,Altieri AS, Mazzulla MJ, Horita DA, Coats RH, Wingfield PT, Das A, Court DL, Byrd RA Nat Struct Biol. 2000 Jun;7(6):470-4. PMID:10881193<ref>PMID:10881193</ref> | ||
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| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| - | </div> | ||
| - | <div class="pdbe-citations 1ey1" style="background-color:#fffaf0;"></div> | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Altieri | + | [[Category: Altieri AS]] |
| - | [[Category: Byrd | + | [[Category: Byrd RA]] |
| - | [[Category: Coats | + | [[Category: Coats RH]] |
| - | [[Category: Horita | + | [[Category: Horita DA]] |
| - | [[Category: Mazzulla | + | [[Category: Mazzulla MJ]] |
| - | [[Category: Wingfield | + | [[Category: Wingfield PT]] |
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Revision as of 10:07, 20 March 2024
SOLUTION STRUCTURE OF ESCHERICHIA COLI NUSB
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