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1ey2

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{{STRUCTURE_1ey2| PDB=1ey2 | SCENE= }}
 
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===HUMAN HOMOGENTISATE DIOXYGENASE WITH FE(II)===
 
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{{ABSTRACT_PUBMED_10876237}}
 
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==Disease==
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==HUMAN HOMOGENTISATE DIOXYGENASE WITH FE(II)==
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[[http://www.uniprot.org/uniprot/HGD_HUMAN HGD_HUMAN]] Defects in HGD are the cause of alkaptonuria (AKU) [MIM:[http://omim.org/entry/203500 203500]]. AKU is an autosomal recessive error of metabolism characterized by an increase in the level of homogentisic acid. The clinical manifestations of AKU are urine that turns dark on standing and alkalinization, black ochronotic pigmentation of cartilage and collagenous tissues, and spine arthritis.<ref>PMID:8782815</ref><ref>PMID:9154114</ref><ref>PMID:9529363</ref><ref>PMID:9630082</ref><ref>PMID:10205262</ref><ref>PMID:10340975</ref><ref>PMID:10482952</ref><ref>PMID:10594001</ref>
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<StructureSection load='1ey2' size='340' side='right'caption='[[1ey2]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1ey2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EY2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EY2 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ey2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ey2 OCA], [https://pdbe.org/1ey2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ey2 RCSB], [https://www.ebi.ac.uk/pdbsum/1ey2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ey2 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/HGD_HUMAN HGD_HUMAN] Defects in HGD are the cause of alkaptonuria (AKU) [MIM:[https://omim.org/entry/203500 203500]. AKU is an autosomal recessive error of metabolism characterized by an increase in the level of homogentisic acid. The clinical manifestations of AKU are urine that turns dark on standing and alkalinization, black ochronotic pigmentation of cartilage and collagenous tissues, and spine arthritis.<ref>PMID:8782815</ref> <ref>PMID:9154114</ref> <ref>PMID:9529363</ref> <ref>PMID:9630082</ref> <ref>PMID:10205262</ref> <ref>PMID:10340975</ref> <ref>PMID:10482952</ref> <ref>PMID:10594001</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/HGD_HUMAN HGD_HUMAN]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ey/1ey2_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ey2 ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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[[1ey2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EY2 OCA].
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*[[Dioxygenase 3D structures|Dioxygenase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:010876237</ref><references group="xtra"/><references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Homogentisate 1,2-dioxygenase]]
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[[Category: Large Structures]]
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[[Category: Cordoba, S M.de.]]
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[[Category: Mueller HA]]
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[[Category: Mueller, H A.]]
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[[Category: Penalva MA]]
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[[Category: Penalva, M A.]]
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[[Category: Timm DE]]
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[[Category: Timm, D E.]]
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[[Category: Titus GP]]
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[[Category: Titus, G P.]]
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[[Category: De Cordoba SM]]
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[[Category: Beta sandwich]]
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[[Category: Jelly roll]]
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[[Category: Oxidoreductase]]
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Current revision

HUMAN HOMOGENTISATE DIOXYGENASE WITH FE(II)

PDB ID 1ey2

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