This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1ey2

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:07, 20 March 2024) (edit) (undo)
 
(12 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1ey2.png|left|200px]]
 
-
<!--
+
==HUMAN HOMOGENTISATE DIOXYGENASE WITH FE(II)==
-
The line below this paragraph, containing "STRUCTURE_1ey2", creates the "Structure Box" on the page.
+
<StructureSection load='1ey2' size='340' side='right'caption='[[1ey2]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1ey2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EY2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EY2 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-
{{STRUCTURE_1ey2| PDB=1ey2 | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ey2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ey2 OCA], [https://pdbe.org/1ey2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ey2 RCSB], [https://www.ebi.ac.uk/pdbsum/1ey2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ey2 ProSAT]</span></td></tr>
 +
</table>
 +
== Disease ==
 +
[https://www.uniprot.org/uniprot/HGD_HUMAN HGD_HUMAN] Defects in HGD are the cause of alkaptonuria (AKU) [MIM:[https://omim.org/entry/203500 203500]. AKU is an autosomal recessive error of metabolism characterized by an increase in the level of homogentisic acid. The clinical manifestations of AKU are urine that turns dark on standing and alkalinization, black ochronotic pigmentation of cartilage and collagenous tissues, and spine arthritis.<ref>PMID:8782815</ref> <ref>PMID:9154114</ref> <ref>PMID:9529363</ref> <ref>PMID:9630082</ref> <ref>PMID:10205262</ref> <ref>PMID:10340975</ref> <ref>PMID:10482952</ref> <ref>PMID:10594001</ref>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/HGD_HUMAN HGD_HUMAN]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ey/1ey2_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ey2 ConSurf].
 +
<div style="clear:both"></div>
-
===HUMAN HOMOGENTISATE DIOXYGENASE WITH FE(II)===
+
==See Also==
-
 
+
*[[Dioxygenase 3D structures|Dioxygenase 3D structures]]
-
 
+
== References ==
-
<!--
+
<references/>
-
The line below this paragraph, {{ABSTRACT_PUBMED_10876237}}, adds the Publication Abstract to the page
+
__TOC__
-
(as it appears on PubMed at http://www.pubmed.gov), where 10876237 is the PubMed ID number.
+
</StructureSection>
-
-->
+
-
{{ABSTRACT_PUBMED_10876237}}
+
-
 
+
-
==About this Structure==
+
-
1EY2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EY2 OCA].
+
-
 
+
-
==Reference==
+
-
Crystal structure of human homogentisate dioxygenase., Titus GP, Mueller HA, Burgner J, Rodriguez De Cordoba S, Penalva MA, Timm DE, Nat Struct Biol. 2000 Jul;7(7):542-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10876237 10876237]
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Homogentisate 1,2-dioxygenase]]
+
[[Category: Large Structures]]
-
[[Category: Single protein]]
+
[[Category: Mueller HA]]
-
[[Category: Cordoba, S M.de.]]
+
[[Category: Penalva MA]]
-
[[Category: Mueller, H A.]]
+
[[Category: Timm DE]]
-
[[Category: Penalva, M A.]]
+
[[Category: Titus GP]]
-
[[Category: Timm, D E.]]
+
[[Category: De Cordoba SM]]
-
[[Category: Titus, G P.]]
+
-
[[Category: Beta sandwich]]
+
-
[[Category: Jelly roll]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:11:52 2008''
+

Current revision

HUMAN HOMOGENTISATE DIOXYGENASE WITH FE(II)

PDB ID 1ey2

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ey2"
Personal tools