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1eyw

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[[Image:1eyw.png|left|200px]]
 
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{{STRUCTURE_1eyw| PDB=1eyw | SCENE= }}
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==THREE-DIMENSIONAL STRUCTURE OF THE ZINC-CONTAINING PHOSPHOTRIESTERASE WITH BOUND SUBSTRATE ANALOG TRIETHYLPHOSPHATE==
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<StructureSection load='1eyw' size='340' side='right'caption='[[1eyw]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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===THREE-DIMENSIONAL STRUCTURE OF THE ZINC-CONTAINING PHOSPHOTRIESTERASE WITH BOUND SUBSTRATE ANALOG TRIETHYLPHOSPHATE===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1eyw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Brevundimonas_diminuta Brevundimonas diminuta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EYW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EYW FirstGlance]. <br>
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{{ABSTRACT_PUBMED_10871616}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene>, <scene name='pdbligand=PEL:2-PHENYL-ETHANOL'>PEL</scene>, <scene name='pdbligand=TEN:TRIETHYL+PHOSPHATE'>TEN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1eyw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1eyw OCA], [https://pdbe.org/1eyw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1eyw RCSB], [https://www.ebi.ac.uk/pdbsum/1eyw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1eyw ProSAT]</span></td></tr>
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[[1eyw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Brevundimonas_diminuta Brevundimonas diminuta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EYW OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/OPD_BREDI OPD_BREDI] Has an unusual substrate specificity for synthetic organophosphate triesters and phosphorofluoridates. All of the phosphate triesters found to be substrates are synthetic compounds. The identity of any naturally occurring substrate for the enzyme is unknown. Has no detectable activity with phosphate monoesters or diesters and no activity as an esterase or protease. It catalyzes the hydrolysis of the insecticide paraoxon at a rate approaching the diffusion limit and thus appears to be optimally evolved for utilizing this synthetic substrate.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ey/1eyw_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1eyw ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Phosphotriesterase|Phosphotriesterase]]
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*[[Phosphotriesterase 3D structures|Phosphotriesterase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:010871616</ref><references group="xtra"/>
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[[Category: Aryldialkylphosphatase]]
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[[Category: Brevundimonas diminuta]]
[[Category: Brevundimonas diminuta]]
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[[Category: Benning, M M.]]
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[[Category: Large Structures]]
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[[Category: Holden, H M.]]
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[[Category: Benning MM]]
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[[Category: Hong, S B.]]
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[[Category: Holden HM]]
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[[Category: Raushel, F M.]]
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[[Category: Hong S-B]]
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[[Category: Hydrolase]]
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[[Category: Raushel FM]]
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[[Category: Organophosphate]]
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Current revision

THREE-DIMENSIONAL STRUCTURE OF THE ZINC-CONTAINING PHOSPHOTRIESTERASE WITH BOUND SUBSTRATE ANALOG TRIETHYLPHOSPHATE

PDB ID 1eyw

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