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1f4g

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{{Seed}}
 
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[[Image:1f4g.png|left|200px]]
 
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==CRYSTAL STRUCTURE OF E. COLI THYMIDYLATE SYNTHASE COMPLEXED WITH SP-876==
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The line below this paragraph, containing "STRUCTURE_1f4g", creates the "Structure Box" on the page.
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<StructureSection load='1f4g' size='340' side='right'caption='[[1f4g]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1f4g]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F4G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1F4G FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CXM:N-CARBOXYMETHIONINE'>CXM</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MHO:S-OXYMETHIONINE'>MHO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TP4:N-[4-[[GLUTAMIC+ACID]-CARBONYL]-BENZENE-SULFONYL-D-PROLINYL]-3-AMINO-PROPANOIC+ACID'>TP4</scene></td></tr>
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{{STRUCTURE_1f4g| PDB=1f4g | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1f4g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f4g OCA], [https://pdbe.org/1f4g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1f4g RCSB], [https://www.ebi.ac.uk/pdbsum/1f4g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1f4g ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TYSY_ECOLI TYSY_ECOLI] Provides the sole de novo source of dTMP for DNA biosynthesis. This protein also binds to its mRNA thus repressing its own translation.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f4/1f4g_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1f4g ConSurf].
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<div style="clear:both"></div>
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===CRYSTAL STRUCTURE OF E. COLI THYMIDYLATE SYNTHASE COMPLEXED WITH SP-876===
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==See Also==
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*[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]]
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__TOC__
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 10944209 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10944209}}
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==About this Structure==
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1F4G is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F4G OCA].
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==Reference==
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Site-directed ligand discovery., Erlanson DA, Braisted AC, Raphael DR, Randal M, Stroud RM, Gordon EM, Wells JA, Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9367-72. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10944209 10944209]
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Thymidylate synthase]]
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[[Category: Braisted AC]]
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[[Category: Braisted, A C.]]
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[[Category: Erlanson DA]]
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[[Category: Erlanson, D A.]]
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[[Category: Gordon E]]
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[[Category: Gordon, E.]]
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[[Category: Randal M]]
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[[Category: Randal, M.]]
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[[Category: Raphael DR]]
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[[Category: Raphael, D R.]]
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[[Category: Stroud RM]]
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[[Category: Stroud, R M.]]
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[[Category: Wells JA]]
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[[Category: Wells, J A.]]
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[[Category: Crystal structure of e. coli thymidylate synthase complexed with sp-876]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:40:26 2008''
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Current revision

CRYSTAL STRUCTURE OF E. COLI THYMIDYLATE SYNTHASE COMPLEXED WITH SP-876

PDB ID 1f4g

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