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1f6f

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[[Image:1f6f.gif|left|200px]]<br /><applet load="1f6f" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1f6f, resolution 2.3&Aring;" />
 
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'''CRYSTAL STRUCTURE OF THE TERNARY COMPLEX BETWEEN OVINE PLACENTAL LACTOGEN AND THE EXTRACELLULAR DOMAIN OF THE RAT PROLACTIN RECEPTOR'''<br />
 
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==Overview==
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==CRYSTAL STRUCTURE OF THE TERNARY COMPLEX BETWEEN OVINE PLACENTAL LACTOGEN AND THE EXTRACELLULAR DOMAIN OF THE RAT PROLACTIN RECEPTOR==
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The structure of the ternary complex between ovine placental lactogen (oPL) and the extracellular domain (ECD) of the rat prolactin receptor (rPRLR) reveals that two rPRLR ECDs bind to opposite sides of oPL with pseudo two-fold symmetry. The two oPL receptor binding sites differ significantly in their topography and electrostatic character. These binding interfaces also involve different hydrogen bonding and hydrophobic packing patterns compared to the structurally related human growth hormone (hGH)-receptor complexes. Additionally, the receptor-receptor interactions are different from those of the hGH-receptor complex. The conformational adaptability of prolactin and growth hormone receptors is evidenced by the changes in local conformations of the receptor binding loops and more global changes induced by shifts in the angular relationships between the N- and C-terminal domains, which allow the receptor to bind to the two topographically distinct sites of oPL.
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<StructureSection load='1f6f' size='340' side='right'caption='[[1f6f]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1f6f]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Ovis_aries Ovis aries] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F6F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1F6F FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1f6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f6f OCA], [https://pdbe.org/1f6f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1f6f RCSB], [https://www.ebi.ac.uk/pdbsum/1f6f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1f6f ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CSH_SHEEP CSH_SHEEP]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f6/1f6f_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1f6f ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1F6F is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Ovis_aries Ovis aries] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F6F OCA].
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*[[Prolactin receptor|Prolactin receptor]]
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__TOC__
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==Reference==
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</StructureSection>
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Ternary complex between placental lactogen and the extracellular domain of the prolactin receptor., Elkins PA, Christinger HW, Sandowski Y, Sakal E, Gertler A, de Vos AM, Kossiakoff AA, Nat Struct Biol. 2000 Sep;7(9):808-15. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10966654 10966654]
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[[Category: Large Structures]]
[[Category: Ovis aries]]
[[Category: Ovis aries]]
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[[Category: Protein complex]]
 
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Christinger, H W.]]
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[[Category: Christinger HW]]
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[[Category: Elkins, P A.]]
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[[Category: De Vos AM]]
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[[Category: Gertler, A.]]
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[[Category: Elkins PA]]
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[[Category: Kossiakoff, A A.]]
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[[Category: Gertler A]]
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[[Category: Sakal, E.]]
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[[Category: Kossiakoff AA]]
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[[Category: Sandowski, Y.]]
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[[Category: Sakal E]]
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[[Category: Vos, A M.De.]]
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[[Category: Sandowski Y]]
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[[Category: 4-helical bundle]]
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[[Category: alpha helical bundle]]
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[[Category: beta sheet domains]]
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[[Category: cytokine-receptor complex]]
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[[Category: fn iii domains]]
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[[Category: ternary complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:35:22 2008''
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Current revision

CRYSTAL STRUCTURE OF THE TERNARY COMPLEX BETWEEN OVINE PLACENTAL LACTOGEN AND THE EXTRACELLULAR DOMAIN OF THE RAT PROLACTIN RECEPTOR

PDB ID 1f6f

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