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1f6l

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{{Seed}}
 
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[[Image:1f6l.png|left|200px]]
 
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==VARIABLE LIGHT CHAIN DIMER OF ANTI-FERRITIN ANTIBODY==
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The line below this paragraph, containing "STRUCTURE_1f6l", creates the "Structure Box" on the page.
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<StructureSection load='1f6l' size='340' side='right'caption='[[1f6l]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1f6l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F6L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1F6L FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1f6l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f6l OCA], [https://pdbe.org/1f6l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1f6l RCSB], [https://www.ebi.ac.uk/pdbsum/1f6l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1f6l ProSAT]</span></td></tr>
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{{STRUCTURE_1f6l| PDB=1f6l | SCENE= }}
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</table>
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== Function ==
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===VARIABLE LIGHT CHAIN DIMER OF ANTI-FERRITIN ANTIBODY===
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[https://www.uniprot.org/uniprot/KV139_HUMAN KV139_HUMAN] V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).<ref>PMID:17576170</ref> <ref>PMID:20176268</ref> <ref>PMID:22158414</ref> <ref>PMID:24600447</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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<!--
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Check<jmol>
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The line below this paragraph, {{ABSTRACT_PUBMED_12217656}}, adds the Publication Abstract to the page
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 12217656 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f6/1f6l_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_12217656}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1f6l ConSurf].
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1F6L is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F6L OCA].
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<div style="clear:both"></div>
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== References ==
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==Reference==
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<references/>
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Antiferritin VL homodimer binds human spleen ferritin with high specificity., Nymalm Y, Kravchuk Z, Salminen T, Chumanevich AA, Dubnovitsky AP, Kankare J, Pentikainen O, Lehtonen J, Arosio P, Martsev S, Johnson MS, J Struct Biol. 2002 Jun;138(3):171-86. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12217656 12217656]
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Arosio, P.]]
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[[Category: Arosio P]]
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[[Category: Chumanevich, A A.]]
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[[Category: Chumanevich AA]]
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[[Category: Dubnovitsky, A P.]]
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[[Category: Dubnovitsky AP]]
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[[Category: Johnson, M S.]]
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[[Category: Johnson MS]]
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[[Category: Kankare, J.]]
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[[Category: Kankare J]]
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[[Category: Kravchuk, Z.]]
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[[Category: Kravchuk Z]]
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[[Category: Lehtonen, J.]]
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[[Category: Lehtonen J]]
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[[Category: Martsev, S.]]
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[[Category: Martsev S]]
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[[Category: Nymalm, Y.]]
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[[Category: Nymalm Y]]
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[[Category: Pentikainen, O.]]
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[[Category: Pentikainen O]]
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[[Category: Salminen, T.]]
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[[Category: Salminen T]]
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[[Category: Anti-ferritin antibody]]
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[[Category: Dimer]]
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[[Category: Immunoglobulin fold]]
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[[Category: Variable light chain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:47:05 2008''
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Current revision

VARIABLE LIGHT CHAIN DIMER OF ANTI-FERRITIN ANTIBODY

PDB ID 1f6l

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