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1f8t

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[[Image:1f8t.jpg|left|200px]]
 
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{{Structure
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==FAB (LNKB-2) OF MONOCLONAL ANTIBODY, CRYSTAL STRUCTURE==
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|PDB= 1f8t |SIZE=350|CAPTION= <scene name='initialview01'>1f8t</scene>, resolution 2.2&Aring;
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<StructureSection load='1f8t' size='340' side='right'caption='[[1f8t]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1f8t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F8T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1F8T FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1f8t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f8t OCA], [https://pdbe.org/1f8t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1f8t RCSB], [https://www.ebi.ac.uk/pdbsum/1f8t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1f8t ProSAT]</span></td></tr>
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}}
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f8/1f8t_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1f8t ConSurf].
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<div style="clear:both"></div>
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'''FAB (LNKB-2) OF MONOCLONAL ANTIBODY, CRYSTAL STRUCTURE'''
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==See Also==
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*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
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__TOC__
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==Overview==
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</StructureSection>
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The three-dimensional structure of the antigen-binding fragment of a monoclonal antibody to human interleukin-2 was determined in two crystal forms by the X-ray method of molecular replacement at 2.2 and 2.9 A resolutions. The spatial structure of the protein and the stereochemistry of its antigen-binding site were analyzed.
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[[Category: Large Structures]]
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==About this Structure==
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1F8T is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F8T OCA].
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==Reference==
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[Spatial structure of a Fab-fragment of a monoclonal antibody to human interleukin-2 in two crystalline forms at a resolution of 2.2 and 2.9 angstroms], Fokin AV, Afonin PV, Mikhailova IIu, Tsygannik IN, Mareeva TIu, Nesmeianov VA, Pangborn W, Lee N, Duax W, Siszak E, Pletnev VZ, Bioorg Khim. 2000 Aug;26(8):571-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11040993 11040993]
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Protein complex]]
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[[Category: Afonin PV]]
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[[Category: Afonin, P V.]]
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[[Category: Fokin AV]]
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[[Category: Fokin, A V.]]
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[[Category: Mareeva TI]]
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[[Category: Mareeva, T I.]]
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[[Category: Mikhailova II]]
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[[Category: Mikhailova, I I.]]
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[[Category: Tsygannik IN]]
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[[Category: Tsygannik, I N.]]
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[[Category: antigen-binding fragment]]
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[[Category: crystal]]
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[[Category: interleukin-2]]
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[[Category: monoclonal antibody]]
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[[Category: x-ray analysis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:05:55 2008''
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Current revision

FAB (LNKB-2) OF MONOCLONAL ANTIBODY, CRYSTAL STRUCTURE

PDB ID 1f8t

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