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1f8u

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{{Seed}}
 
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[[Image:1f8u.png|left|200px]]
 
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<!--
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==CRYSTAL STRUCTURE OF MUTANT E202Q OF HUMAN ACETYLCHOLINESTERASE COMPLEXED WITH GREEN MAMBA VENOM PEPTIDE FASCICULIN-II==
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The line below this paragraph, containing "STRUCTURE_1f8u", creates the "Structure Box" on the page.
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<StructureSection load='1f8u' size='340' side='right'caption='[[1f8u]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1f8u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Dendroaspis_angusticeps Dendroaspis angusticeps] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F8U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1F8U FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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{{STRUCTURE_1f8u| PDB=1f8u | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1f8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f8u OCA], [https://pdbe.org/1f8u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1f8u RCSB], [https://www.ebi.ac.uk/pdbsum/1f8u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1f8u ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ACES_HUMAN ACES_HUMAN] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis.<ref>PMID:2714437</ref> <ref>PMID:1748670</ref> <ref>PMID:1517212</ref> <ref>PMID:11985878</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f8/1f8u_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1f8u ConSurf].
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<div style="clear:both"></div>
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===CRYSTAL STRUCTURE OF MUTANT E202Q OF HUMAN ACETYLCHOLINESTERASE COMPLEXED WITH GREEN MAMBA VENOM PEPTIDE FASCICULIN-II===
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==See Also==
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*[[Acetylcholinesterase 3D structures|Acetylcholinesterase 3D structures]]
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*[[Fasciculin|Fasciculin]]
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== References ==
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The line below this paragraph, {{ABSTRACT_PUBMED_11053835}}, adds the Publication Abstract to the page
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<references/>
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(as it appears on PubMed at http://www.pubmed.gov), where 11053835 is the PubMed ID number.
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__TOC__
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</StructureSection>
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{{ABSTRACT_PUBMED_11053835}}
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==Disease==
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Known disease associated with this structure: Blood group, Yt system OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=100740 100740]]
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==About this Structure==
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1F8U is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Dendroaspis_angusticeps Dendroaspis angusticeps] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F8U OCA].
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==Reference==
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<ref group="xtra">PMID:11053835</ref><references group="xtra"/>
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[[Category: Acetylcholinesterase]]
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[[Category: Dendroaspis angusticeps]]
[[Category: Dendroaspis angusticeps]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Harel, M.]]
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[[Category: Large Structures]]
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[[Category: Kryger, G.]]
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[[Category: Harel M]]
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[[Category: Shafferman, A.]]
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[[Category: Kryger G]]
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[[Category: Silman, I.]]
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[[Category: Shafferman A]]
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[[Category: Sussman, J L.]]
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[[Category: Silman I]]
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[[Category: Human acetylcholinesterase]]
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[[Category: Sussman JL]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase/hydrolase inhibitor]]
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[[Category: Serine esterase]]
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[[Category: Snake toxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 22:01:11 2009''
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Current revision

CRYSTAL STRUCTURE OF MUTANT E202Q OF HUMAN ACETYLCHOLINESTERASE COMPLEXED WITH GREEN MAMBA VENOM PEPTIDE FASCICULIN-II

PDB ID 1f8u

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