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1f97

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{{Seed}}
 
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[[Image:1f97.png|left|200px]]
 
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==SOLUBLE PART OF THE JUNCTION ADHESION MOLECULE FROM MOUSE==
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The line below this paragraph, containing "STRUCTURE_1f97", creates the "Structure Box" on the page.
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<StructureSection load='1f97' size='340' side='right'caption='[[1f97]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1f97]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F97 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1F97 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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{{STRUCTURE_1f97| PDB=1f97 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1f97 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f97 OCA], [https://pdbe.org/1f97 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1f97 RCSB], [https://www.ebi.ac.uk/pdbsum/1f97 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1f97 ProSAT]</span></td></tr>
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</table>
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===SOLUBLE PART OF THE JUNCTION ADHESION MOLECULE FROM MOUSE===
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== Function ==
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[https://www.uniprot.org/uniprot/JAM1_MOUSE JAM1_MOUSE] Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation. In case of orthoreovirus infection, serves as receptor for the virus (By similarity).
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== Evolutionary Conservation ==
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<!--
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_11500366}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 11500366 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f9/1f97_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_11500366}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1F97 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F97 OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1f97 ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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X-ray structure of junctional adhesion molecule: structural basis for homophilic adhesion via a novel dimerization motif., Kostrewa D, Brockhaus M, D'Arcy A, Dale GE, Nelboeck P, Schmid G, Mueller F, Bazzoni G, Dejana E, Bartfai T, Winkler FK, Hennig M, EMBO J. 2001 Aug 15;20(16):4391-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11500366 11500366]
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Single protein]]
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[[Category: Bazzoni G]]
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[[Category: Arcy, A D.]]
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[[Category: Brockhaus M]]
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[[Category: Bazzoni, G.]]
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[[Category: D'Arcy A]]
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[[Category: Brockhaus, M.]]
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[[Category: Dale G]]
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[[Category: Dale, G.]]
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[[Category: Dejana E]]
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[[Category: Dejana, E.]]
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[[Category: Hennig M]]
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[[Category: Hennig, M.]]
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[[Category: Kostrewa D]]
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[[Category: Kostrewa, D.]]
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[[Category: Winkler F]]
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[[Category: Winkler, F.]]
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[[Category: Beta-sandwich fold]]
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[[Category: Immunoglobulin superfamily]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:54:00 2008''
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Current revision

SOLUBLE PART OF THE JUNCTION ADHESION MOLECULE FROM MOUSE

PDB ID 1f97

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