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1fc4

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{{Seed}}
 
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[[Image:1fc4.png|left|200px]]
 
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<!--
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==2-AMINO-3-KETOBUTYRATE COA LIGASE==
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The line below this paragraph, containing "STRUCTURE_1fc4", creates the "Structure Box" on the page.
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<StructureSection load='1fc4' size='340' side='right'caption='[[1fc4]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1fc4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FC4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FC4 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AKB:2-AMINO-3-KETOBUTYRIC+ACID'>AKB</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
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{{STRUCTURE_1fc4| PDB=1fc4 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fc4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fc4 OCA], [https://pdbe.org/1fc4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fc4 RCSB], [https://www.ebi.ac.uk/pdbsum/1fc4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fc4 ProSAT], [https://www.topsan.org/Proteins/BSGI/1fc4 TOPSAN]</span></td></tr>
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</table>
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===2-AMINO-3-KETOBUTYRATE COA LIGASE===
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== Function ==
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[https://www.uniprot.org/uniprot/KBL_ECOLI KBL_ECOLI] Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.<ref>PMID:2104756</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 11318637 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fc/1fc4_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_11318637}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1FC4 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FC4 OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fc4 ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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Three-dimensional structure of 2-amino-3-ketobutyrate CoA ligase from Escherichia coli complexed with a PLP-substrate intermediate: inferred reaction mechanism., Schmidt A, Sivaraman J, Li Y, Larocque R, Barbosa JA, Smith C, Matte A, Schrag JD, Cygler M, Biochemistry. 2001 May 1;40(17):5151-60. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11318637 11318637]
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<references/>
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Glycine C-acetyltransferase]]
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[[Category: Large Structures]]
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[[Category: BSGI, Montreal-Kingston Bacterial Structural Genomics Initiative.]]
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[[Category: Cygler M]]
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[[Category: Cygler, M.]]
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[[Category: Larocque R]]
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[[Category: Larocque, R.]]
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[[Category: Li Y]]
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[[Category: Li, Y.]]
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[[Category: Matte A]]
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[[Category: Matte, A.]]
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[[Category: Sauve V]]
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[[Category: Sauve, V.]]
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[[Category: Schmidt A]]
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[[Category: Schmidt, A.]]
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[[Category: Schrag JD]]
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[[Category: Schrag, J D.]]
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[[Category: Sivaraman J]]
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[[Category: Sivaraman, J.]]
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[[Category: Smith C]]
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[[Category: Smith, C.]]
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[[Category: 2-amino-3-ketobutyrate coa ligase]]
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[[Category: Bsgi]]
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[[Category: Coenzyme some]]
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[[Category: Montreal-kingston bacterial structural genomics initiative]]
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[[Category: Pyridoxal phosphate]]
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[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Nov 16 12:07:34 2008''
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Current revision

2-AMINO-3-KETOBUTYRATE COA LIGASE

PDB ID 1fc4

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