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1ffj
From Proteopedia
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| - | {{Seed}} | ||
| - | [[Image:1ffj.png|left|200px]] | ||
| - | < | + | ==NMR STRUCTURE OF CARDIOTOXIN IN DPC-MICELLE== |
| - | + | <StructureSection load='1ffj' size='340' side='right'caption='[[1ffj]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1ffj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Naja_oxiana Naja oxiana]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FFJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FFJ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ffj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ffj OCA], [https://pdbe.org/1ffj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ffj RCSB], [https://www.ebi.ac.uk/pdbsum/1ffj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ffj ProSAT]</span></td></tr> | |
| - | + | </table> | |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/3SA2_NAJOX 3SA2_NAJOX] This three-finger cytotoxin is a basic protein that interacts and penetrates into the cell membrane, with the tips of all the three loops. Cytotoxins which have a Pro-30 (P-type) interacts with membrane stronger that those which have a 'Ser-28' (S-type). CTII interacts with membrane stronger than CTI.<ref>PMID:11357394</ref> <ref>PMID:12709064</ref> <ref>PMID:15584897</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ff/1ffj_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ffj ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | == | + | ==See Also== |
| - | + | *[[Cardiotoxin 3D structures|Cardiotoxin 3D structures]] | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | [[Category: Large Structures]] | |
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| - | == | + | |
| - | < | + | |
[[Category: Naja oxiana]] | [[Category: Naja oxiana]] | ||
| - | [[Category: Arseniev | + | [[Category: Arseniev AS]] |
| - | [[Category: Bocharov | + | [[Category: Bocharov EV]] |
| - | [[Category: Dementieva | + | [[Category: Dementieva DV]] |
| - | [[Category: Dubovskii | + | [[Category: Dubovskii PV]] |
| - | [[Category: Utkin | + | [[Category: Utkin YN]] |
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Current revision
NMR STRUCTURE OF CARDIOTOXIN IN DPC-MICELLE
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