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1fih

From Proteopedia

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[[Image:1fih.png|left|200px]]
 
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{{STRUCTURE_1fih| PDB=1fih | SCENE= }}
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==N-ACETYLGALACTOSAMINE BINDING MUTANT OF MANNOSE-BINDING PROTEIN A (QPDWG-HDRPY), COMPLEX WITH N-ACETYLGALACTOSAMINE==
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<StructureSection load='1fih' size='340' side='right'caption='[[1fih]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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===N-ACETYLGALACTOSAMINE BINDING MUTANT OF MANNOSE-BINDING PROTEIN A (QPDWG-HDRPY), COMPLEX WITH N-ACETYLGALACTOSAMINE===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1fih]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FIH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FIH FirstGlance]. <br>
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{{ABSTRACT_PUBMED_10931846}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fih OCA], [https://pdbe.org/1fih PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fih RCSB], [https://www.ebi.ac.uk/pdbsum/1fih PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fih ProSAT]</span></td></tr>
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[[1fih]] is a 3 chain structure of [[Mannose-binding protein]] with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FIH OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MBL1_RAT MBL1_RAT] Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fi/1fih_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fih ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
*[[Mannose-binding protein|Mannose-binding protein]]
*[[Mannose-binding protein|Mannose-binding protein]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:010931846</ref><references group="xtra"/>
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[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Drickamer, K.]]
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[[Category: Drickamer K]]
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[[Category: Feinberg, H.]]
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[[Category: Feinberg H]]
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[[Category: Torgerson, D.]]
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[[Category: Torgerson D]]
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[[Category: Weis, W I.]]
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[[Category: Weis WI]]
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[[Category: C-type lectin]]
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[[Category: Calcium-binding protein]]
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[[Category: Lectin]]
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[[Category: Sugar binding protein]]
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Current revision

N-ACETYLGALACTOSAMINE BINDING MUTANT OF MANNOSE-BINDING PROTEIN A (QPDWG-HDRPY), COMPLEX WITH N-ACETYLGALACTOSAMINE

PDB ID 1fih

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OCA

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