Cephalosporin acylase
From Proteopedia
(Difference between revisions)
| (One intermediate revision not shown.) | |||
| Line 1: | Line 1: | ||
<StructureSection load='1jw0' size='350' side='right' caption='Cephalosporin acylase α subunit (magenta) and β subunit (green) complex with glutarate (PDB entry [[1jw0]])' scene='52/525143/Cv/1'> | <StructureSection load='1jw0' size='350' side='right' caption='Cephalosporin acylase α subunit (magenta) and β subunit (green) complex with glutarate (PDB entry [[1jw0]])' scene='52/525143/Cv/1'> | ||
| - | '''Cephalosporin acylase''' (CSA) catalyzes the conversion of cephalosporin C (CPC) to 7-amino-cephalosporanic acid (7-ACA).<ref>PMID:11080627</ref> | + | '''Cephalosporin acylase''' (CSA) catalyzes the conversion of [[cephalosporin]] C (CPC) to 7-amino-cephalosporanic acid (7-ACA).<ref>PMID:11080627</ref> |
== Relevance == | == Relevance == | ||
| Line 15: | Line 15: | ||
</StructureSection> | </StructureSection> | ||
| - | ==3D structures of cephalosporin acylase== | ||
| - | |||
| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | |||
| - | *Cephalosporin acylase | ||
| - | |||
| - | **[[2nlz]] - CSA – ''Bacillus halodurans''<br /> | ||
| - | **[[1fm2]] - BdCSA – ''Brevundimonas diminuta''<br /> | ||
| - | **[[1gk0]], [[1gk1]], [[1ghd]], [[4hsr]], [[4hst]] - PsCSA – ''Pseudomonas''<br /> | ||
| - | **[[2ae3]], [[2ae5]], [[3jtq]], [[2adv]] - PsCSA α + β (mutant) subunits<br /> | ||
| - | **[[2ae4]], [[4e55]], [[4e56]], [[4e57]], [[3jtr]] - PsCSA α (mutant) + β subunits<br /> | ||
| - | **[[1keh]] - BdCSA precursor (mutant) | ||
| - | |||
| - | *Cephalosporin acylase complex | ||
| - | **[[1jvz]] – BdCSA + glutaryl-7-ACA<br /> | ||
| - | **[[1jw0]] - BdCSA + glutarate | ||
| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
| |||||||||||
References
- ↑ Kim Y, Yoon K, Khang Y, Turley S, Hol WG. The 2.0 A crystal structure of cephalosporin acylase. Structure. 2000 Oct 15;8(10):1059-68. PMID:11080627
- ↑ Kim Y, Hol WG. Structure of cephalosporin acylase in complex with glutaryl-7-aminocephalosporanic acid and glutarate: insight into the basis of its substrate specificity. Chem Biol. 2001 Dec;8(12):1253-64. PMID:11755403
