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8w3v

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(New page: '''Unreleased structure''' The entry 8w3v is ON HOLD Authors: Hutchinson, A., Dong, A., Li, Y., Seitova, A., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Halabelian, L., Structural Gen...)
Current revision (10:06, 27 March 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8w3v is ON HOLD
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==Crystal structure of human WDR41==
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<StructureSection load='8w3v' size='340' side='right'caption='[[8w3v]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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Authors: Hutchinson, A., Dong, A., Li, Y., Seitova, A., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Halabelian, L., Structural Genomics Consortium (SGC)
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8w3v]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=6whh 6whh]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8W3V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8W3V FirstGlance]. <br>
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Description: Crystal structure of human WDR41
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8w3v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8w3v OCA], [https://pdbe.org/8w3v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8w3v RCSB], [https://www.ebi.ac.uk/pdbsum/8w3v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8w3v ProSAT]</span></td></tr>
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[[Category: Hutchinson, A]]
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</table>
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[[Category: Edwards, A.M]]
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== Function ==
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[[Category: Arrowsmith, C.H]]
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[https://www.uniprot.org/uniprot/WDR41_HUMAN WDR41_HUMAN] Non-catalytic component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:27193190, PubMed:27103069, PubMed:27617292, PubMed:28195531). The C9orf72-SMCR8 complex promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (PubMed:27103069). The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activity (PubMed:27103069, PubMed:27617292).<ref>PMID:27103069</ref> <ref>PMID:27193190</ref> <ref>PMID:27617292</ref> <ref>PMID:28195531</ref>
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[[Category: Seitova, A]]
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== References ==
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[[Category: Dong, A]]
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<references/>
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[[Category: Structural Genomics Consortium (Sgc)]]
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__TOC__
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[[Category: Li, Y]]
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</StructureSection>
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[[Category: Halabelian, L]]
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[[Category: Homo sapiens]]
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[[Category: Bountra, C]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra C]]
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[[Category: Dong A]]
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[[Category: Edwards AM]]
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[[Category: Halabelian L]]
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[[Category: Hutchinson A]]
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[[Category: Li Y]]
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[[Category: Seitova A]]

Current revision

Crystal structure of human WDR41

PDB ID 8w3v

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