This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
8ogm
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 8ogm is ON HOLD Authors: Garbers, T.B., Neumann, P., Weiss, M.S., Wollenhaupt, J., Ficner, R. Description: Crystal structure of CdaA from Bacillus ...) |
|||
| (2 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of CdaA from Bacillus subtilis== | |
| - | + | <StructureSection load='8ogm' size='340' side='right'caption='[[8ogm]], [[Resolution|resolution]] 1.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8ogm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis_subsp._subtilis_str._168 Bacillus subtilis subsp. subtilis str. 168]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8OGM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8OGM FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.1Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ogm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ogm OCA], [https://pdbe.org/8ogm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ogm RCSB], [https://www.ebi.ac.uk/pdbsum/8ogm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ogm ProSAT]</span></td></tr> |
| - | [[Category: Ficner | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: Neumann | + | [https://www.uniprot.org/uniprot/CDAA_BACSU CDAA_BACSU] One of 3 paralogous diadenylate cyclases (DAC) in this bacteria, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP) (Probable). Upon expression in E.coli leads to c-di-AMP synthesis (PubMed:23192352). Probably the main producer of c-di-AMP for the cell; is probably implicated in control of peptidogylcan synthesis (PubMed:22211522, PubMed:23192352, PubMed:26240071). In B.subtilis c-di-AMP is a second messenger that mediates growth, DNA repair and cell wall homeostasis; it is toxic when present in excess (PubMed:26240071).<ref>PMID:23192352</ref> <ref>PMID:26240071</ref> <ref>PMID:22211522</ref> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Bacillus subtilis subsp. subtilis str. 168]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Ficner R]] | ||
| + | [[Category: Garbers TB]] | ||
| + | [[Category: Neumann P]] | ||
| + | [[Category: Weiss MS]] | ||
| + | [[Category: Wollenhaupt J]] | ||
Current revision
Crystal structure of CdaA from Bacillus subtilis
| |||||||||||
