5xuy

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==Crystal structure of ATG101-ATG13HORMA==
==Crystal structure of ATG101-ATG13HORMA==
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<StructureSection load='5xuy' size='340' side='right' caption='[[5xuy]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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<StructureSection load='5xuy' size='340' side='right'caption='[[5xuy]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5xuy]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XUY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XUY FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5xuy]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XUY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5XUY FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xuy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xuy OCA], [http://pdbe.org/5xuy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xuy RCSB], [http://www.ebi.ac.uk/pdbsum/5xuy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xuy ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5xuy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xuy OCA], [https://pdbe.org/5xuy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5xuy RCSB], [https://www.ebi.ac.uk/pdbsum/5xuy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5xuy ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ATG13_HUMAN ATG13_HUMAN]] Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.<ref>PMID:19287211</ref> <ref>PMID:19211835</ref> <ref>PMID:19225151</ref> <ref>PMID:21855797</ref> <ref>PMID:18936157</ref> <ref>PMID:21795849</ref> [[http://www.uniprot.org/uniprot/ATGA1_HUMAN ATGA1_HUMAN]] Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation.<ref>PMID:19287211</ref> <ref>PMID:19597335</ref>
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[https://www.uniprot.org/uniprot/ATG13_HUMAN ATG13_HUMAN] Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.<ref>PMID:19287211</ref> <ref>PMID:19211835</ref> <ref>PMID:19225151</ref> <ref>PMID:21855797</ref> <ref>PMID:18936157</ref> <ref>PMID:21795849</ref>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Kim, B W]]
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[[Category: Homo sapiens]]
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[[Category: Song, H K]]
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[[Category: Large Structures]]
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[[Category: Atg101]]
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[[Category: Kim B-W]]
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[[Category: Atg13]]
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[[Category: Song HK]]
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[[Category: Autophagy]]
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[[Category: Horma]]
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[[Category: Protein binding]]
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Current revision

Crystal structure of ATG101-ATG13HORMA

PDB ID 5xuy

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