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5ysm

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==Crystal Structure Analysis of Rif16==
==Crystal Structure Analysis of Rif16==
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<StructureSection load='5ysm' size='340' side='right' caption='[[5ysm]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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<StructureSection load='5ysm' size='340' side='right'caption='[[5ysm]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5ysm]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YSM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YSM FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5ysm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Amycolatopsis_mediterranei_U32 Amycolatopsis mediterranei U32]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YSM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5YSM FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ysm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ysm OCA], [http://pdbe.org/5ysm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ysm RCSB], [http://www.ebi.ac.uk/pdbsum/5ysm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ysm ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ysm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ysm OCA], [https://pdbe.org/5ysm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ysm RCSB], [https://www.ebi.ac.uk/pdbsum/5ysm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ysm ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/A0A0H3CVZ6_AMYMU A0A0H3CVZ6_AMYMU]
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Rifamycin-derived drugs, including rifampin, rifabutin, rifapentine, and rifaximin, have long been used as first-line therapies for the treatment of tuberculosis and other deadly infections. However, the late steps leading to the biosynthesis of the industrially important rifamycin SV and B remain largely unknown. Here, we characterize a network of reactions underlying the biosynthesis of rifamycin SV, S, L, O, and B. The two-subunit transketolase Rif15 and the cytochrome P450 enzyme Rif16 are found to mediate, respectively, a unique C-O bond formation in rifamycin L and an atypical P450 ester-to-ether transformation from rifamycin L to B. Both reactions showcase interesting chemistries for these two widespread and well-studied enzyme families.
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Deciphering the late steps of rifamycin biosynthesis.,Qi F, Lei C, Li F, Zhang X, Wang J, Zhang W, Fan Z, Li W, Tang GL, Xiao Y, Zhao G, Li S Nat Commun. 2018 Jun 14;9(1):2342. doi: 10.1038/s41467-018-04772-x. PMID:29904078<ref>PMID:29904078</ref>
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==See Also==
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*[[Cytochrome P450 3D structures|Cytochrome P450 3D structures]]
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 5ysm" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Li, F W]]
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[[Category: Amycolatopsis mediterranei U32]]
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[[Category: Li, S Y]]
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[[Category: Large Structures]]
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[[Category: Qi, F F]]
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[[Category: Li FW]]
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[[Category: Xiao, Y L]]
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[[Category: Li SY]]
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[[Category: Zhao, G P]]
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[[Category: Qi FF]]
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[[Category: Cytochrome p450]]
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[[Category: Xiao YL]]
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[[Category: Metal binding protein]]
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[[Category: Zhao GP]]
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[[Category: Oxidoreductase]]
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[[Category: Rifamycin]]
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Current revision

Crystal Structure Analysis of Rif16

PDB ID 5ysm

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