This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
5z9k
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==BRD4 Bromodomain 1 with an inhibitor== | ==BRD4 Bromodomain 1 with an inhibitor== | ||
| - | <StructureSection load='5z9k' size='340' side='right'caption='[[5z9k]]' scene=''> | + | <StructureSection load='5z9k' size='340' side='right'caption='[[5z9k]], [[Resolution|resolution]] 1.89Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z9K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5Z9K FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5z9k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z9K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5Z9K FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5z9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z9k OCA], [https://pdbe.org/5z9k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5z9k RCSB], [https://www.ebi.ac.uk/pdbsum/5z9k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5z9k ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.89Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=99X:1-ethyl-6-[(2R)-2-(hydroxymethyl)pyrrolidin-1-yl]sulfonyl-benzo[cd]indol-2-one'>99X</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5z9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z9k OCA], [https://pdbe.org/5z9k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5z9k RCSB], [https://www.ebi.ac.uk/pdbsum/5z9k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5z9k ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | ||
==See Also== | ==See Also== | ||
*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]] | *[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Chen H]] | [[Category: Chen H]] | ||
[[Category: Chen S]] | [[Category: Chen S]] | ||
[[Category: Xiao S]] | [[Category: Xiao S]] | ||
Current revision
BRD4 Bromodomain 1 with an inhibitor
| |||||||||||
Categories: Homo sapiens | Large Structures | Chen H | Chen S | Xiao S
