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5zlp

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==Crystal structure of glutamine synthetase from helicobacter pylori==
==Crystal structure of glutamine synthetase from helicobacter pylori==
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<StructureSection load='5zlp' size='340' side='right' caption='[[5zlp]], [[Resolution|resolution]] 2.93&Aring;' scene=''>
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<StructureSection load='5zlp' size='340' side='right'caption='[[5zlp]], [[Resolution|resolution]] 2.93&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5zlp]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZLP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZLP FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5zlp]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori_26695 Helicobacter pylori 26695]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZLP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZLP FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=P3P:(2S)-2-AMINO-4-[METHYL(PHOSPHONOOXY)PHOSPHORYL]BUTANOIC+ACID'>P3P</scene>, <scene name='pdbligand=PPQ:PHOSPHINOTHRICIN'>PPQ</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.93&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamate--ammonia_ligase Glutamate--ammonia ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.1.2 6.3.1.2] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=P3P:(2S)-2-AMINO-4-[METHYL(PHOSPHONOOXY)PHOSPHORYL]BUTANOIC+ACID'>P3P</scene>, <scene name='pdbligand=PPQ:PHOSPHINOTHRICIN'>PPQ</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zlp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zlp OCA], [http://pdbe.org/5zlp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zlp RCSB], [http://www.ebi.ac.uk/pdbsum/5zlp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zlp ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zlp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zlp OCA], [https://pdbe.org/5zlp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zlp RCSB], [https://www.ebi.ac.uk/pdbsum/5zlp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zlp ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GLN1B_HELPY GLN1B_HELPY]] Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia.[UniProtKB:P0A1P6]
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[https://www.uniprot.org/uniprot/GLN1B_HELPY GLN1B_HELPY] Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia.[UniProtKB:P0A1P6]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Glutamine synthetase (GS) is an enzyme that regulates nitrogen metabolism and synthesizes glutamine via glutamate, ATP, and ammonia. GS is a homo-oligomeric protein of eight, ten, or twelve subunits, and each subunit-subunit interface has its own active site. GS can be divided into GS I, GS II, and GS III. GS I and GS III form dodecamer in bacteria and archaea, whereas GS II form decamer in eukaryotes. GS I can be further subdivided into GS I-alpha and GS I-beta according to its sequence and regulatory mechanism. GS is an essential protein for the survival of Helicobacter pylori which its infection could promote gastroduodenal diseases. Here, we determined the crystal structures of the GS from H. pylori (Hpy GS) in its apo- and substrate-bound forms at 2.8 A and 2.9 A resolution, respectively. Hpy GS formed a dodecamer composed of two hexameric rings stacked face-to-face. Hpy GS, which belongs to GS I, cannot be clearly classified as either GS I-alpha or GS I-beta based on its sequence and regulatory mechanism. In this study, we propose that Hpy GS could be classified as a new GS-I subfamily and provide structural information on the apo- and substrate-bound forms of the protein.
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Structural Analysis of Glutamine Synthetase from Helicobacter pylori.,Joo HK, Park YW, Jang YY, Lee JY Sci Rep. 2018 Aug 3;8(1):11657. doi: 10.1038/s41598-018-30191-5. PMID:30076387<ref>PMID:30076387</ref>
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==See Also==
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*[[Glutamine synthetase 3D structures|Glutamine synthetase 3D structures]]
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 5zlp" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Glutamate--ammonia ligase]]
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[[Category: Helicobacter pylori 26695]]
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[[Category: Joo, H K]]
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[[Category: Large Structures]]
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[[Category: Lee, J Y]]
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[[Category: Joo HK]]
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[[Category: Enzyme]]
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[[Category: Lee JY]]
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[[Category: Glutamine synthetase]]
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[[Category: Helicobacter pylori]]
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[[Category: Ligase]]
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[[Category: Structural protein]]
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Current revision

Crystal structure of glutamine synthetase from helicobacter pylori

PDB ID 5zlp

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