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6j0m

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Current revision (10:36, 27 March 2024) (edit) (undo)
 
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<SX load='6j0m' size='340' side='right' viewer='molstar' caption='[[6j0m]], [[Resolution|resolution]] 3.90&Aring;' scene=''>
<SX load='6j0m' size='340' side='right' viewer='molstar' caption='[[6j0m]], [[Resolution|resolution]] 3.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6j0m]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43950 Atcc 43950]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6J0M OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6J0M FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6j0m]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Photorhabdus_asymbiotica Photorhabdus asymbiotica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6J0M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6J0M FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6j0m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6j0m OCA], [http://pdbe.org/6j0m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6j0m RCSB], [http://www.ebi.ac.uk/pdbsum/6j0m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6j0m ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6j0m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6j0m OCA], [https://pdbe.org/6j0m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6j0m RCSB], [https://www.ebi.ac.uk/pdbsum/6j0m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6j0m ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/B6VNN7_PHOAA B6VNN7_PHOAA]
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Contractile injection systems (CISs) are cell-puncturing nanodevices that share ancestry with contractile tail bacteriophages. Photorhabdus virulence cassette (PVC) represents one group of extracellular CISs that are present in both bacteria and archaea. Here, we report the cryo-EM structure of an intact PVC from P. asymbiotica. This over 10-MDa device resembles a simplified T4 phage tail, containing a hexagonal baseplate complex with six fibers and a capped 117-nanometer sheath-tube trunk. One distinct feature of the PVC is the presence of three variants for both tube and sheath proteins, indicating a functional specialization of them during evolution. The terminal hexameric cap docks onto the topmost layer of the inner tube and locks the outer sheath in pre-contraction state with six stretching arms. Our results on the PVC provide a framework for understanding the general mechanism of widespread CISs and pave the way for using them as delivery tools in biological or therapeutic applications.
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Cryo-EM Structure and Assembly of an Extracellular Contractile Injection System.,Jiang F, Li N, Wang X, Cheng J, Huang Y, Yang Y, Yang J, Cai B, Wang YP, Jin Q, Gao N Cell. 2019 Apr 4;177(2):370-383.e15. doi: 10.1016/j.cell.2019.02.020. Epub 2019, Mar 21. PMID:30905475<ref>PMID:30905475</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 6j0m" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</SX>
</SX>
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[[Category: Atcc 43950]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Cai, B]]
 
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[[Category: Cheng, J]]
 
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[[Category: Gao, N]]
 
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[[Category: Huang, Y]]
 
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[[Category: Jiang, F]]
 
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[[Category: Jin, Q]]
 
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[[Category: Li, N]]
 
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[[Category: Wang, X]]
 
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[[Category: Wang, Y]]
 
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[[Category: Yang, J]]
 
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[[Category: Yang, Y]]
 
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[[Category: Assembly]]
 
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[[Category: Bacteriophage-like]]
 
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[[Category: Contractile injection system]]
 
[[Category: Photorhabdus asymbiotica]]
[[Category: Photorhabdus asymbiotica]]
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[[Category: Protein transport]]
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[[Category: Cai B]]
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[[Category: Pvc]]
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[[Category: Cheng J]]
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[[Category: Gao N]]
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[[Category: Huang Y]]
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[[Category: Jiang F]]
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[[Category: Jin Q]]
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[[Category: Li N]]
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[[Category: Wang X]]
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[[Category: Wang Y]]
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[[Category: Yang J]]
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[[Category: Yang Y]]

Current revision

Cryo-EM Structure of an Extracellular Contractile Injection System, PVC baseplate in extended state (reconstructed with C3 symmetry)

6j0m, resolution 3.90Å

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