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6j6w

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Current revision (10:37, 27 March 2024) (edit) (undo)
 
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<StructureSection load='6j6w' size='340' side='right'caption='[[6j6w]], [[Resolution|resolution]] 1.69&Aring;' scene=''>
<StructureSection load='6j6w' size='340' side='right'caption='[[6j6w]], [[Resolution|resolution]] 1.69&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6j6w]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6J6W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6J6W FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6j6w]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6J6W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6J6W FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.693&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6j6w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6j6w OCA], [http://pdbe.org/6j6w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6j6w RCSB], [http://www.ebi.ac.uk/pdbsum/6j6w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6j6w ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6j6w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6j6w OCA], [https://pdbe.org/6j6w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6j6w RCSB], [https://www.ebi.ac.uk/pdbsum/6j6w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6j6w ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/HSF4_HUMAN HSF4_HUMAN]] Early-onset lamellar cataract;Total early-onset cataract. The disease is caused by mutations affecting the gene represented in this entry.
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[https://www.uniprot.org/uniprot/HSF4_HUMAN HSF4_HUMAN] Early-onset lamellar cataract;Total early-onset cataract. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/HSF4_HUMAN HSF4_HUMAN]] DNA-binding protein that specifically binds heat shock promoter elements (HSE). Isoform HSF4A represses transcription while the isoform HSF4B activates transcription.<ref>PMID:16371476</ref>
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[https://www.uniprot.org/uniprot/HSF4_HUMAN HSF4_HUMAN] DNA-binding protein that specifically binds heat shock promoter elements (HSE). Isoform HSF4A represses transcription while the isoform HSF4B activates transcription.<ref>PMID:16371476</ref>
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==See Also==
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*[[Heat shock factor|Heat shock factor]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Cui, L W]]
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[[Category: Cui LW]]
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[[Category: Liu, W]]
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[[Category: Liu W]]
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[[Category: Wang, S]]
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[[Category: Wang S]]
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[[Category: Xiao, Z Y]]
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[[Category: Xiao ZY]]
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[[Category: Transcription]]
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[[Category: Transcriptional factor]]
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Current revision

Mutant K23N of heat shock factor 4-DBD

PDB ID 6j6w

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